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Treatment of ankylosing spondylitis with TNFα inhibitors does not affect serum levels of tryptophan metabolites
The imbalance between the kynurenine and serotonin pathways can have serious consequences, e.g., depression. One of the factors leading to the...
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The Role of H3K27me3-Mediated Th17 Differentiation in Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a common chronic progressive inflammatory autoimmune disease. T helper 17 (Th17) cells are the major effector cells...
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MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis
Ankylosing spondylitis (AS) is an autoinflammatory disease that affects the sacroiliac joints, causing stiffness and pain in the back. MICA is a...
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DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis
Ankylosing spondylitis (AS) is an autoimmune-related inflammatory arthritis. The association between the DNA methylation and mRNA expression of PDCD1 ...
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SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling
Ankylosing spondylitis (AS) is an autoimmune disease which associated with inflammation of the spinal joints. Enhanced osteogenic differentiation was...
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Microorganisms in the Pathogenesis and Management of Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic systemic auto-inflammatory disease that mainly affects sacroiliac joints and the axial skeleton. AS shows...
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Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis
Various lymphocyte subpopulations, including NK cells as well as γδ T cells, have been considered an important element in the pathogenesis of...
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STAT3 and SPI1, may lead to the immune system dysregulation and heterotopic ossification in ankylosing spondylitis
ObjectiveThis study was aimed to identify the biomarkers for diagnosis and reveal the immune microenvironment changes in ankylosing spondylitis (AS).
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Long noncoding RNA intersectin 1-2 gradually declines during adalimumab treatment, and its reduction correlates with treatment efficacy in patients with ankylosing spondylitis
Previous studies show that long noncoding RNA intersectin 1-2 (lnc-ITSN1-2) promotes the inflammation process and serves as a potential biomarker in...
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Analysis of inflammation-related microRNA expression in patients with ankylosing spondylitis
Ankylosing spondylitis (AS) is a complex genetic disease characterized by axial skeletal inflammation. Available scientific evidence suggests that a...
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Comparison of the antibacterial activity of Australian Terminalia spp. extracts against Klebsiella pneumoniae: a potential treatment for ankylosing spondylitis
Traditional medicines prepared using Terminalia species have been used globally to treat inflammation and pathogenic infections. Recent studies have...
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Upregulation of Unfolded Protein Response and ER Stress–Related IL-23 Production in M1 Macrophages from Ankylosing Spondylitis Patients
The inflammatory interleukin (IL)-23/IL-17 axis plays an important role in the pathogenesis of ankylosing spondylitis (AS), but with an unknown...
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Immune-related adverse events (irAEs) in ankylosing spondylitis (AS) patients treated with interleukin (IL)-17 inhibitors: a systematic review and meta-analysis
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by immune system dysregulation and inflammation in...
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Janus kinase inhibitors for treating active ankylosing spondylitis: a meta-analysis of randomized controlled trials
ObjectiveIn this study, we aimed to assess the safety and efficacy of Janus kinase (JAK) inhibitors in patients with ankylosing spondylitis (AS).
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Quality of internet videos related to exercise therapy of ankylosing spondylitis from mainland China
ObjectiveThe aim of this study is to assess the quality and reliability of online videos on ankylosing spondylitis (AS) exercises from the five most...
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Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study
To explore the association between methylation level and transcript level of TNF receptor-associated factor 5 (TRAF5) gene with ankylosing...
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Aberrant antigen processing and presentation: Key pathogenic factors leading to immune activation in Ankylosing spondylitis
The strong association of HLA-B*27 with ankylosing spondylitis (AS) was first reported nearly 50 years ago. However, the mechanistic link between...
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Spondyloarthropathies and arthritis post-infection: a historical perspective
The spondyloarthropathies are a group of conditions characterised by spinal joint pain and have related clinical, epidemiological and genetic-related...
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Circulating interleukin-23 levels in ankylosing spondylitis and their correlation with disease activity
ObjectiveTo systematically investigate the relationship between circulating interleukin-23 (IL‑23) levels and ankylosing spondylitis (AS) and...
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Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis
Ankylosing spondylitis (AS) is a chronic inflammatory disease possessing a morbid serum microenvironment with enhanced oxidative stress. Long-term...
