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Cognitive asymmetry in rats in response to emergent vs. disappearing affordances
This study examines the effects of novel environmental changes on the behavior of rats in an experimental chamber. We hypothesized that newly...
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White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans
Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer’s disease in mouse models. However, clinical...
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Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study
Telomeres undergo a progressive shortening process as individuals age, and it has been proposed that severely shortened and dysfunctional telomeres...
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The influence of sex-specific factors on biological transformations and health outcomes in aging processes
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The...
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Exploring the complexity of EEG patterns in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily associated with motor dysfunctions. By the time of definitive...
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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation
The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to...
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1)...
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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice
Various approaches exist to quantify the aging process and estimate biological age on an individual level. Frailty indices based on an age-related...
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Association between dietary (poly)phenol intake and the ATHLOS Healthy Ageing Scale in the Polish arm of the HAPIEE study
Inverse association between (poly)phenol intake and age-related disorders has been demonstrated; however, little is known whether they affect...
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Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation
Phylloquinon (PK) and menaquinones (MK) are both naturally occurring compounds belonging to vitamin K group. Present study aimed to comprehensively...
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Are comparable studies really comparable? Suggestions from a problem-solving experiment on urban and rural great tits
Performance in tests of various cognitive abilities has often been compared, both within and between species. In intraspecific comparisons, habitat...
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Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice
As individuals age, there is a gradual decline in cardiopulmonary function, often accompanied by cardiac pump dysfunction leading to increased...
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Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty...
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High rate of potentially inappropriate medication use in older people: a case–control study
Annually, 172 million fall events cause temporary or permanent impairment in older adults, and this number is increasing. Contributing factors that...
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Integrated renal and sympathetic mechanisms underlying the development of sex- and age-dependent hypertension and the salt sensitivity of blood pressure
Aging is a non-modifiable understudied risk factor for hypertension. We hypothesized that sympathetically mediated activation of renal sodium...
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Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study...
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in...
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Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice
BRG1 (Brahma-related gene 1) is a member of the SWI/SNF (switch/sucrose nonfermentable) chromatin remodeling complex which utilizes the energy from...
