25 Result(s)
within
Biomedicine
Pharmacology/Toxicology
Ke** Zhang
Reference Work Entry
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Living Reference Work Entry In depth
Evidence on the Impact of Pharmacogenetics to Treat and Manage Cardiovascular Diseases
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Effective medications for the treatment of cardiovascular diseases include antithrombotic drugs, antihypertensive drugs, and ...
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Reference Work Entry In depth
Biomarkers of PM2.5 Exposure: Use of Metabolomics as a Platform
Pollution of particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) is the most rapidly increasing cause of global burden of diseases. Biomarkers are frequently assessed to reflect the level ...
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Reference Work Entry In depth
Epigenetics and 5-Hydroxymethylcytosines as a Biomarker in Type 2 Diabetes
Type 2 diabetes (T2D) is a lifelong chronic condition that impairs the body’s normal function of regulating and using sugar (glucose) for energy. Continuous high blood sugar levels will eventually damage vital...
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Reference Work Entry In depth
Murine Embryonic Stem Cells as Platform for Toxicity Studies: Use of Human Survivin Promoter with Green Fluorescent Protein Reporter for High-Throughput Screening
Embryonic and fetal development is a complicated process regulated by many signaling pathways and transcriptional factors that can be negatively impacted by drug or chemical exposure during pregnancy. It is ur...
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Living Reference Work Entry In depth
Biomarkers of PM2.5 Exposure: Use of Metabolomics as a Platform
Pollution of particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) is the most rapidly increasing cause of global burden of diseases. Biomarkers are frequently assessed to reflect the level ...
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Living Reference Work Entry In depth
Patient Safety from a Pharmacy Perspective
Patient safety is a common language to all healthcare professionals. Providing safe and effective patient-centered care is what healthcare professionals embrace and strive for every day. Pharmacy practice is a...
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Living Reference Work Entry In depth
Murine Embryonic Stem Cells as Platform for Toxicity Studies: Use of Human Survivin Promoter with Green Fluorescent Protein Reporter for High-Throughput Screening
Embryonic and fetal development is a complicated process regulated by many signaling pathways and transcriptional factors that can be negatively impacted by drug or chemical exposure during pregnancy. It is ur...
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Living Reference Work Entry In depth
Epigenetics and 5-Hydroxymethylcytosines as a Biomarker in Type 2 Diabetes
Type 2 diabetes (T2D) is a lifelong chronic condition that impairs the body’s normal function of regulating and using sugar (glucose) for energy. Continuous high blood sugar levels will eventually damage vital...
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Reference Work Entry In depth
MUC1
MUC1 mucin was the first molecule expressed by human tumor cells to be shown as a target for human antibodies and T cells. It belongs to a large family of shared, non-mutated tumor associated antigens differen...
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Reference Work Entry In depth
CCL21
Chemokines that attract both dendritic cells (DC) and lymphocyte effectors can aid in cancer immunotherapy by enlisting host immune cells to recognize tumors of low immunogenicity. CCL21 mediates the recruitme...
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Reference Work Entry In depth
ROS
Cancer cells have increased generation of reactive oxygen species (ROS). A moderate increase in ROS can promote cell proliferation and differentiation, but excessive amounts of ROS cause oxidative damage to ca...
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Reference Work Entry In depth
Metals and Autoimmune Disease
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Reference Work Entry In depth
Pulse Pressure and Pulse Pressure Amplification as Biomarkers in Cardiovascular Disease
Recent evidence indicated that pulse pressure and pulse pressure amplification, the ratio or difference between the peripheral and central pulse pressure, might provide prognostic information in patients with ...
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Living Reference Work Entry In depth
Independent Origins of Scorpion Toxins Affecting Potassium and Sodium Channels
Peptide neurotoxins targeting sodium (Na+) and potassium (K+) channels are two major components of scorpion venom for capturing prey (e.g., insects) and deterring competitors (e.g., small mammals). Although a gre...
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Living Reference Work Entry In depth
Structure, Enterotoxicity, and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Stable Type I Toxin (STa) and Derivatives
Heat-stable toxin type I (STa) is one of the two major types of enterotoxins produced by enterotoxigenic Escherichia coli (ETEC) bacteria that cause children’s diarrhea and travelers’ diarrhea. STa toxicity and i...
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Living Reference Work Entry In depth
ROS
Cancer cells have increased generation of reactive oxygen species (ROS). A moderate increase in ROS can promote cell proliferation and differentiation, but excessive amounts of ROS cause oxidative damage to ca...
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Living Reference Work Entry In depth
Pulse Pressure and Pulse Pressure Amplification as Biomarkers in Cardiovascular Disease
Recent evidence indicated that pulse pressure and pulse pressure amplification, the ratio or difference between the peripheral and central pulse pressure, might provide prognostic information in patients with ...
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Reference Work Entry In depth
Biomarkers of Parkinson’s Disease
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, and its prevalence is expected to increase as the population ages. The earliest symptoms of PD are subtle and nonspecific, complic...
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Living Reference Work Entry In depth
Metals and Autoimmune Disease
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Reference Work Entry In depth
Reactive Oxygen Species and Antioxidants in Pancreatic β-Cell Function – Yin and Yang
Although cytotoxic, reactive oxygen species (ROS) also function as important intracellular signaling molecules for cellular responses to a variety of physiological stimuli including glucose sensing and insulin...
