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Living Reference Work Entry In depth
HER Receptor, Current, and Emerging Therapeutic Targets
The human epidermal growth factor receptor (HER/ErbB) family consists of four members: HER-1 or epidermal growth factor receptor (EGFR), HER-2, HER-3, and HER-4. These receptors play a crucial role in regulati...
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Living Reference Work Entry In depth
Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in Cancer
Endoplasmic reticulum stress (ER stress) is characterized by the accumulation of misfolded and unfolded proteins in the ER lumen. To mitigate the imbalanced ER protein-folding capacity, cells activate the unfo...