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Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport
The use of primary neuronal cultures generated from Drosophila tissue provides a powerful model for studies of transport mechanisms. Cultured fly...
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Visualizing the Intracellular Trafficking in Zebrafish Mauthner Cells
Axonal transport is crucial for the development and survival of neurons and maintenance of neuronal function. Disruption in this active process...
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Methods and Applications of Campenot Trichamber Neuronal Cultures for the Study of Neuroinvasive Viruses
The development of compartmentalized neuron culture systems has been invaluable in the study of neuroinvasive viruses, including the alpha...
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Live Imaging and Quantitative Analysis of Organelle Transport in Sensory Neurons of Aplysia Californica
Axonal transport moves proteins, RNAs, and organelles between the soma and synapses to support synaptic function and activity-dependent changes in...
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Live Imaging of Axonal Transport in the Adult Drosophila Central Nervous System
Live imaging of axons allows for the determination of motility and directionality of proteins or organelles. In Drosophila, axonal transport has been...
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Mitochondrial DNA Transport in Drosophila Neurons
Mitochondria are essential organelles that generate energy and play vital roles in cellular metabolism. The small circular mitochondrial genome...
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The Giant Axon of the Squid: A Simple System for Axonal Transport Studies
The squid giant axon has a long history of being a superb experimental system in which to investigate a wide range of questions concerning...
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Microfluidic Neuromuscular Co-culture System for Tracking Cell-to-Cell Transfer and Axonal Transport of Labeled Proteins
The molecular communication mechanisms within the Motor Neurons (MN) distant axon and its soma, as well as between MN and their neighboring cells and...
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Analyzing the Impact of Gene Mutations on Axonal Transport in Caenorhabditis Elegans
The development and functions of neurons are supported by axonal transport. Axonal transport is a complex process whose regulation involves multiple...
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Methods to Quantify and Relate Axonal Transport Defects to Changes in C. elegans Behavior
Neuronal growth, differentiation, homeostasis, viability, and injury response heavily rely on functional axonal transport (AT). Erroneous and...
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Assessment of Mitochondrial Trafficking as a Surrogate for Fast Axonal Transport in Human Induced Pluripotent Stem Cell–Derived Spinal Motor Neurons
Axonal transport is essential for the development, function, and survival of the nervous system. In an energy-demanding process, motor proteins act...
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Imaging Axonal Transport in Ex Vivo Central and Peripheral Nerves
Neurones are highly polarized cells with extensive axonal projections that rely on transport of proteins, RNAs, and organelles in a bidirectional...
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Detailed Imaging of Mitochondrial Transport and Precise Manipulation of Mitochondrial Function with Genetically Encoded Photosensitizers in Adult Drosophila Neurons
Precise distribution of mitochondria is essential for maintaining neuronal homeostasis. Although detailed mechanisms governing the transport of...
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Use of Microfluidics Chambers to Image Axonal transport in Adult Sensory Neurons
Transport of cargoes along axons is crucial for ensuring effective neuronal function and survival. Lysosomes, which are membrane-bound organelles...
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High-Resolution Live Imaging of Axonal RNP Granules in Drosophila Pupal Brain Explants
Dynamic and local adjustments of the axonal proteome are observed in response to extracellular cues and achieved via translation of axonally...
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Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons
Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due...
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Live-Cell Imaging of RNA Transport in Axons of Cultured Primary Neurons
The use of fluorescent proteins has revolutionized the study of protein localization and transport. However, the visualization of other molecules and...
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In Vivo Imaging of Axonal Organelle Transport in the Mouse Brain
Visualization and analysis of axonal organelle transport has been mostly conducted in vitro, using primary neuronal cell cultures, although more...
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Imaging Diversity in Slow Axonal Transport
The polarized morphology of neurons necessitates the delivery of proteins synthesized in the soma along the length of the axon to distal synapses;...
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In Vivo Live Imaging of Axonal Transport in Develo** Zebrafish Axons
Axonal transport is crucial for neuronal homeostasis, survival, and development. Indeed, axonal transport needs to be precisely regulated for...