Search
Search Results
-
Virtual Screening Process: A Guide in Modern Drug Designing
Due to its capacity to drastically cut the cost and time necessary for experimental screening of compounds, virtual screening (VS) has grown to be a...
-
Understanding the Role of Scavenger Receptor A1 in Nanoparticle Uptake by Murine Macrophages
Nanoparticles can be cleared from the circulation and taken up by tissue-resident macrophages. This property can be beneficial when drug or antigen...
-
Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects
Computer-aided drug discovery and design involve the use of information technologies to identify and develop, on a rational ground, chemical...
-
Immunophenoty**, Part I: Instrument Calibration and Reagent Qualification for Immunophenoty** Analysis of Human Peripheral Blood Mononuclear Cell Cultures
Nanoparticles are increasingly used in biomedical applications to influence the way the immune system reacts to tumors and infectious disease-causing...
-
Measuring Size and Number Concentration of Metallic Nanoparticles Using spICP-MS
This protocol describes how to measure the size and concentration of individual metallic nanoparticles using inductively coupled plasma-mass...
-
Methods for Analysis of Nanoparticle Immunosuppressive Properties
Adverse drug effects on immune system function represent a significant concern in the pharmaceutical industry, because 10–20% of drug withdrawal from...
-
Ion Quantitation in Liposomal Products Using RP-HPLC with Charged Aerosol Detection
Ion concentration in liposomal drugs is important for drug stability and drug release profile. However, quantifying ion concentration in liposomal...
-
Applications of Molecular Dynamics Simulations in Drug Discovery
In the current drug development process, molecular dynamics (MD) simulations have proven to be very useful. This chapter provides an overview of the...
-
Accelerating the Discovery and Design of Antimicrobial Peptides with Artificial Intelligence
Peptides modulate many processes of human physiology targeting ion channels, protein receptors, or enzymes. They represent valuable starting points...
-
Detection of Induction of Mitochondrial Oxidative Stress by Nanoparticles in T Cells Using MitoSOX Red Dye
The induction of oxidative stress by engineered nanomaterials has been associated with cytotoxic and inflammatory responses, damaging healthy cells...
-
Evaluation of the Acute Anaphylactoid Reactogenicity of Nanoparticle-Containing Medicines and Vaccines Using the Porcine CARPA Model
A small fraction, up to 10%, of people treated intravenously with state-of-the-art nanoparticulate drugs or diagnostic agents develop an acute...
-
Detection of Intracellular Complement Activation by Nanoparticles in Human T Lymphocytes
The complement system is complex and includes two main components: the systemic or plasma complement and the so-called intracellular complement or...
-
AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
-
Techniques for Develo** Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots
With machine learning now transforming the sciences, successful prediction of biological structure or activity is mainly limited by the extent and...
-
Detection of Antigen Presentation by Murine Bone Marrow–Derived Dendritic Cells After Treatment with Nanoparticles
Nanoparticles are frequently considered in vaccine applications due to their ability to co-deliver multiple antigens and adjuvants to...
-
Detection of Pre-Existing Antibodies to Polyethylene Glycol and PEGylated Liposomes in Human Serum
Polyethylene glycol, or PEG, is common in consumer products, over-the-counter medications, food, and pharmaceutical products. Concerns about PEG...
-
Recent Deep Learning Applications to Structure-Based Drug Design
Identification and optimization of small molecules that bind to and modulate protein function is a crucial step in the early stages of drug...
-
Protein–Ligand Blind Docking Using CB-Dock2
Protein–ligand blind docking is a widely used method for studying the binding sites and poses of ligands and receptors in pharmaceutical and...
-
Detection of Beta-Glucan Contamination in Nanoparticle Formulations
Beta-glucans with diverse chemical structures are produced by a variety of microorganisms and are commonly found in microbial cell walls....
-
Expanding the Landscape of Amyloid Sequences with CARs-DB: A Database of Polar Amyloidogenic Peptides from Disordered Proteins
Several databases collecting amyloidogenic regions have been released to provide information on protein sequences able to form amyloid fibrils....