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    Cellular and Transgenic Models of Familial Prion Diseases

    Prion diseases are fatal neurodegenerative disorders of humans and animals, which result from the conformational conversion of a normal, cell surface glycoprotein (PrPC) into a pathogenic isoform (PrPSc) that is ...

    David A. Harris, Roberto Chiesa, Antonio Migheli… in Molecular Pathology of the Prions (2001)