75,737 Result(s)
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Epidemiological Studies and Occupational Exposures
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Exposure to Metal Carcinogens In The General Population
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In Vitro and Cell Culture Analysis of Metal Carcinogenesis
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Methods for In Vitro Metal Carcinogenesis Testing
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Metal Carcinogenesis In Experimental Animals
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Molecular Mechanisms of Metal Carcinogenesis in Experimental Animals
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Principles of In Vitro Metal Carcinogenesis
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Principles and Methods of Industrial Metal Carcinogenesis Testing
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Tricyclic Antidepressants
The use of tricyclic antidepressant drugs is becoming increasingly prevalent for the treatment of depressed patients. It has been suggested that, analogous to many other drug substances, the tricyclic drugs ex...
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Polyamines
The polyamines spermidine [NH2(CH2)3NH(CH2)4NH2] and spermine [NH2(CH2)3NH(CH2)4NH(CH2)3NH2] and their diamine precursor, putrescine [NH2(CH2)4NH2], have been the subject of intense study relative to their potent...
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Hypnotics and Sedatives
In recent years, most large hospitals have observed a marked increase in the admission of patients suffering from drug overdose. Overdose of narcotic drugs, such as the opiates, represent less of a problem on ...
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Principles of Liquid Chromatography
This article reviews the basic principles of high performance liquid chromatography (HPLC). The introductory section provides an overview of the HPLC technique, placing it in historical context and discussing ...
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Determination of Tyrosine and Tryptophan Metabolites in Body Ruids Using Electrochemical Detection
The amino acids tyrosine and tryptophan are precursors for a number of important physiological compounds. The catecholamines, which are metabolites of tyrosine, serve as neurotransmitters in the central and pe...
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Liquid Chromatography Column Technology
The last decade has seen tremendous advances made in LC columns and column technology. From the development of the pellicular packings in the late 1960s to the 5- to 10-µm microparticles of the 1970s, the colu...
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Proteins
Because of the complexity of cellular material and body fluids, it is seldom possible to analyze a natural product directly. Qualitative and quantitative analyses must often be preceded by some purification st...
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Anticonvulsants
Until recently, it was difficult to explain why an identical drug dosage may exert a toxic effect in one patient and a therapeutic, or no, response in another patient. It has now been demonstrated that the con...
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Porphyrins
Historically the term porphyria has been used since it was coined in 1871 to describe a purple colored material extracted from pathological feces (1). The first case of porphyria was reported in 1874, (2, 3), but...
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Antibiotics
A 28-year-old man was transferred to our hospital and underwent surgery for resection of an aortic graft infected with Klebsiella pneumoniae. Antimicrobial therapy consisted of amikacin, cefazolin, chloramphenico...
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Major and Modified Nucleosides, RNA, and DNA
Most analytical chemists are well aware of the rapid rate of development of high-performance liquid chromatography (HPLC) over the past 5 years. A number of articles have been published in Analytical Chemistry on...
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Antineoplastic Drugs
The limited scope of therapeutic drug-level monitoring in cancer chemotherapy results from the often complex biochemical mechanisms that contribute to antineoplastic activity and obscure the relationships amon...
