186 Result(s)
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Protocol
Confounding in Genetic Association Studies and Its Solutions
An association study can be used to investigate how individuals with unique genetic variants respond to a drug treatment. In an association study, individuals may come from different ethnic groups or an admixe...
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Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy
There is wide variability in the response of individuals to standard doses of drug therapy. This is an important problem in clinical practice, where it can lead to therapeutic failures or adverse drug events. ...
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G Protein-Coupled Receptors Disrupted in Human Genetic Disease
Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR function in a wide variety of human genetic diseases. In vitro strategies have been used to elucidate the molecular pa...
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Pharmacogenetics of Asthma
Asthma is a common disease characterized by airway inflammation and bronchorestriction. There are several common categories of medications for treating asthma; however, not all asthmatics have the same respons...
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Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders
Although there is evidence to link schizophrenia (SCZ) and bipolar disorder (BD) to genetic and environmental factors, specific individual or groups of genes/factors causative of the disease have been elusive ...
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Pharmacogenomics in Gastrointestinal Disorders
It is anticipated that unraveling the human genome will have a direct impact on the management of specific diseases. Variations or mutations in genes involved in drug metabolism or disease pathophysiology in g...
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Cancer Pharmacogenetics
Cancer pharmacogenetics is a burgeoning field. There are now many published associations between genotype and outcome or toxicity from chemotherapy treatment. Performing pharmacogenetics studies in cancer requ...
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Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines
The understanding of vaccine-induced immune responses in adults and infants is limited. Current vaccination schedules for infants are frequently debated. Especially, the relationship among the timing, the freq...
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Applications of Microarrays and Biochips in Pharmacogenomics
The complete sequence of the human genome and subsequent intensive searches for polymorphic variations are providing the prerequisite markers necessary to facilitate elucidation of the genetic variability in d...
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Pharmacogenetics of Membrane Transporters
This chapter provides a review of the pharmacogenetics of mem brane transporters, including adenosine triphosphate-binding cassette (ABC) transporters and organic anion transporting proteins (OATPs). Membrane ...
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Pharmacogenomics of G Protein-Coupled Receptor
The identification and characterization of the processes of G protein-coupled receptor (GPCR) activation and inactivation have refined not only the study of the GPCRs but also the genomics of many accessory pr...
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Pharmacogenomics in Alzheimer's Disease
Pharmacological treatment in Alzheimer's disease (AD) accounts for 10–20% of direct costs, and fewer than 20% of AD patients are moderate responders to conventional drugs (donepezil, rivastigmine, galantamine,...
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G Protein-Coupled Receptor Pharmacogenetics
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor n...
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From SNPs to Functional Studies in Cardiovascular Pharmacogenomics
Functional studies can be utilized to give importance/relevance to clinical associations. Once a clinical genetic or pharmacogenetic association is found, molecular studies can be utilized to explore the mecha...
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Pharmacogenomics in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic inflammatory arthritis that leads to severe joint damage and is associated with high morbidity and mortality. Disease-modifying antirheumatic drugs (DMARDs) are the main...
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Pharmacogenomics in the Preclinical Development of Vaccines
The development of vaccines, conventional protein based as well as nucleic acid based vaccines, and their delivery systems has been largely empirical and ineffective. This is partly due to a lack of methodolog...
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The Integration of Personalized and Systems Medicine
Pharmacogenomics may have a deep impact on every drug treatment protocol to bring the right drug to the right patient. While pharmacogenomics can help achieve individualized medicine, the study of systems biol...
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Molecular Detection of Ralstonia solanacearum to Facilitate Breeding for Resistance to Bacterial Wilt in Potato
Potato bacterial wilt is caused by the devastating bacterial pathogen Ralstonia solanacearum. Quantitative resistance to this disease has been and is currently introgressed from a number of wild relatives into cu...
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Data Processing and Analysis for DIA-Based Phosphoproteomics Using Spectronaut
Data-independent acquisition (DIA) for liquid chromatography tandem mass spectrometry (LC-MS/MS) can improve the depth and reproducibility of the acquired proteomics datasets. DIA solves some limitations of th...
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A Comprehensive Guide to Potato Transcriptome Assembly
We have witnessed a rapid advancement in high-throughput genome sequencing and the maturation of long-read technologies. However, an accurate assembly of polyploid potato genomes still remains challenging. Seq...
