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Structural Classification of CDR-H3 in Single-Domain VHH Antibodies
The immune systems protect vertebrates from foreign molecules or antigens, and antibodies are important mediators of this system. The sequences and structural features of antibodies vary depending on species. ...
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Correction to: DIA Proteomics and Machine Learning for the Fast Identification of Bacterial Species in Biological Samples
The original version of the book was published with an incorrect image for Figure 1 of Chapter 21, which has been corrected by replacing with the correct artwork as given below
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Correction to: Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias
The chapter was inadvertently published with one of the co-author’s surname incorrectly spelled as “Sohljoo” instead of “Solhjoo”
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Analysis of Small RNA Sequencing Data in Plants
Over the past decades, next-generation sequencing (NGS) has been employed extensively for investigating the regulatory mechanisms of small RNAs. Several bioinformatics tools are available for aiding biologists...
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Virtual Populations for Quantitative Systems Pharmacology Models
Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems modeling, incorporating considerations from systems biology modeling and pharmacodynamics. The goal of QSP is often to quantitative...
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Scripting Analyses of Genomes in Ensembl Plants
Ensembl Plants (http://plants.ensembl.org) offers genome-scale information for plants, with four releases per year. As of release 47 (April 2020) it features 79 species ...
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CyVerse for Reproducible Research: RNA-Seq Analysis
Posing complex research questions poses complex reproducibility challenges. Datasets may need to be managed over long periods of time. Reliable and secure repositories are needed for data storage. Sharing big ...
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Correction to: RNA Bioinformatics
In the original version of this book, chapter 8 was published with incomplete list of authors. This has now been rectified in this revised version of the book.
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Correction to: Alignment of Biological Sequences with Jalview
This chapter was mistakenly published non-open access. It has been updated to open access under a CC BY 4.0 license and the Copyright Holder changed to "The Author(s)". The book has also been updated to reflec...
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Correction to: Cryopreservation of Potato Shoot Tips for Long-Term Storage
Chapter 2 was previously published non-open access. It has now been changed to open access under a CC BY 4.0 license, and the copyright holder updated to ‘The Author(s)’. The book has been updated with this ch...
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Correction to: Proteomics Data Analysis
In the original version of this book, chapter 16 was published non-open access. It has now been changed to open access under a CC BY 4.0 license, and the copyright holder has been updated to “The Author(s).” T...
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Correction to: Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center
The book has been inadvertently published with wrong affiliation for the corresponding author, Randa M. Perkins, of chapter 1. It has now been updated as below in this revised version of the book.
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Profiling of RNA Structure at Single-Nucleotide Resolution Using nextPARS
RNA molecules play important roles in almost every cellular process, and their functions are mediated by their sequence and structure. Determining the secondary structure of RNAs is central to understanding RN...
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Deep Learning for Protein–Protein Interaction Site Prediction
Protein–protein interactions (PPIs) are central to cellular functions. Experimental methods for predicting PPIs are well developed but are time and resource expensive and suffer from high false-positive error ...
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Alignment of Biological Sequences with Jalview
In this chapter, we introduce core functionality of the Jalview interactive platform for the creation, analysis, and publication of multiple sequence alignments. A workflow is described based on Jalview’s core...
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Cryopreservation of Potato Shoot Tips for Long-Term Storage
Cryopreservation is currently the only method which allows long-term conservation of living clonal plant material in the vapor or liquid phase of nitrogen (at −140 to −196 °C) allowing tissue to be viable for ...
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RNA-Seq Data Analysis in Galaxy
A complete RNA-Seq analysis involves the use of several different tools, with substantial software and computational requirements. The Galaxy platform simplifies the execution of such bioinformatics analyses b...
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Correction to: Statistical Population Genomics
Chapter 2, “Processing and Analyzing Multiple Genomes Alignments with MafFilter,” was previously published without including the Electronic Supplementary Material. This has now been included in the revised ver...
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Population Genomics in the Great Apes
The great apes play an important role as model organisms. They are our closest living relatives, allowing us to identify the genetic basis of phenotypic traits that we think of as characteristically human. How...
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Biological Assembly Comparison with VAST+
The VAST+ algorithm is an efficient, simple, and elegant solution to the problem of comparing the atomic structures of biological assemblies. Given two protein assemblies, it takes as input all the pairwise st...