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    Topoisomerase I and II Activity Assays

    DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes that play an essential role in transcription, replication, chromosome segregation, and DNA repair. The basic enzymatic reaction ...

    Philippe Pourquier, Glenda Kohlhagen, Li-Ming Ueng… in Cytotoxic Drug Resistance Mechanisms (1999)