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Inexpensive and colorimetric RNA detection at ambient temperature with a cell-free protein synthesis platform
While many proposals of paper-based diagnostics utilize cell-free gene expression systems, these assays oftentimes suffer from the need for...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Hydrogels for Musculoskeletal Tissue Engineering
The advancements in scaffold-supported cell therapy for musculoskeletal tissue engineering have been truly dramatic in the last couple of decades....
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes
A wide variety of highly selective asymmetric reactions catalyzed by chiral (salen)metal complexes have been disclosed over the past decade. Salen...
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Molecular Components of Physiological Stress Responses in Escherichia coli
In order to survive under and adapt to different conditions Escherichia coli has evolved elaborate systems that are able to sense and respond to...
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Hydrozirconation and Its Applications
Next to hydroboration and hydrostannylation, hydrozirconation is among the few general methods available for the stoichiometric conversion of readily...
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Electron Spin Resonance Spectroscopy
The theoretical principles of the ESR technique and its application in the field of molecular sieve science are reviewed. The first part of this...
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Gene expression modulation tools for bacterial synthetic biology
Synthetic biology has revolutionized the creation of microbial cell factories for the efficient production of value-added chemicals and materials...
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Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
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Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules
Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying...
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Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use...
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Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,...
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Organolithium in Asymmetric Processes
The development of asymmetric processes has been the focus of industrial research as most of the molecules of pharmaceutical interest contain chiral...
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Applications of Organotitanium Reagents
Organometallic transformations involving titanium are employed both catalytically and stoichiometrically in the pharmaceutical and fine chemical...
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Rhodium/Ruthenium Applications
Asymmetric catalytic hydrogenation and hydrogen transfer reactions of various substrates such as prochiral ketones and olefins using Rh(I) and Ru(II)...
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Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
The utility of inter- and intramolecular Heck arylations in the synthesis of intermediates for the preparation of active pharmaceutical ingredients...