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Greater Self-reported Health is Associated with Lower Disgust: Evidence for Individual Calibration of the Behavioral Immune System
A key theoretical component of the behavioral immune system is its functional flexibility, where an individual’s reaction to pathogenic stimuli is...
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Efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
Aims/hypothesisThe aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese...
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Strategies for modeling aging and age-related diseases
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and...
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MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome
BackgroundPolycystic ovary syndrome (PCOS), the most common endocrine disorder in premenopausal women, is associated with increased obesity,...
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Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Aims/hypothesisAlterations in circadian rhythms increase the likelihood of develo** type 2 diabetes and CVD. Circadian rhythms are controlled by...
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Modulation of miR-155-5p signalling via 5-ASA for the prevention of high microsatellite instability: an in vitro study using human epithelial cell lines
5-aminosalicylic acid (5-ASA) is a first-line treatment for maintaining colitis remission. It is a highly effective, safe, and well-tolerated drug...
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Influence of sustained mild dehydration on thermoregulatory and cognitive functions during prolonged moderate exercise
PurposeThe current study investigated whether sustained mild dehydration affects thermoregulatory function and cognitive performance during prolonged...
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Revised cardiac risk index in predicting cardiovascular complications in patients receiving chronic kidney replacement therapy undergoing elective general surgery
IntroductionThe Revised Cardiac Risk Index (RCRI) is a six-parameter model that is commonly used in assessing individual 30-day perioperative...
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Efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
Aims/hypothesisThe aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population...
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Research hotspots and trends of spinal cord stimulation for neuropathic pain: a bibliometric analysis from 2004 to 2023
The purpose of this study is to systematically analyze the development trend, research hotspots, and future development direction on the treatment of...
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Investigation of macro and micro sleep structures of first night effect in school-aged children
This study aimed to investigate the occurrence and age-related changes of the first night effect (FNE) in school-age children using both macro (sleep...
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Neurobiology of Obsessive–Compulsive Disorder from Genes to Circuits: Insights from Animal Models
Obsessive-compulsive disorder (OCD) is a chronic, severe psychiatric disorder that has been ranked by the World Health Organization as one of the...
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Exploring the complex associations among risks of malnutrition, sarcopenia, and frailty in community-dwelling older adults
BackgroundMalnutrition, sarcopenia, and frailty are age-related conditions that are associated with multiple health-related negative outcomes....
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Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State
The nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the...
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Terminologia Anatomica 2nd edition: perspectives from anatomy educators in the United Kingdom
English anatomical terminology has evolved over the long history of anatomical practice, with major influences from ancient Greek, classical Latin,...
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A modified step–ramp–step protocol to prescribe constant-speed exercise in treadmill running
PurposeThis study investigated whether a running-adapted version of the cycling-based “step–ramp–step” (SRS) protocol would improve prediction of
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Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle
Resistance training activates mammalian target of rapamycin (mTOR) pathway of hypertrophy for strength gain, while endurance training increases...
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Silencing of ultradian rhythms and metabolic depression during spontaneous daily torpor in Djungarian hamsters
Ultradian rhythms of metabolism, body temperature and activity are attenuated or disappear completely during torpor in Djungarian hamsters, for all...
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ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis
Medulloblastoma is the most common malignant tumor in the pediatric population. Its classification has incorporated key molecular variations...
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Polarized running training adapted to versus contrary to the menstrual cycle phases has similar effects on endurance performance and cardiovascular parameters
PurposeThis study compared the effects of polarized running training adapted to the menstrual cycle (MC) phases versus polarized training adapted...
