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Chapter and Conference Paper
Genetic Background of Japanese Patients with Nonalcoholic Steatohepatitis (NASH)
The pathogenesis of nonalcoholic steatohepatitis (NASH) is not understood well. Therefore, it is necessary to examine genetic influences on NASH pathogenesis. Two functional polymorphisms were studied: the −49...
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Chapter and Conference Paper
Quantitative Determination of Bcl-2 Expression in AML Cell Lines and in Normal and Leukemic Progenitor Cell Compartments by Laser Scanning Cytometry: Comparison with Flow Cytometry and Western Blot
Laser Scanning Cytometry (LSC) is a newly developed microscope-based and computerized system that directly analyzes up to 3- color fluorescence simultaneously from single cells attached to slides. It permits c...
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Chapter and Conference Paper
Leukemia Stem Cells with Efficient Drug Efflux in Acute Myeloid Leukemia
Phenotypical dissection of the cellular heterogeneity in acute myeloid leukemia (AML) has recently dissolved this disease in a hierarchical organization of subpopulations with divergent proliferative potential...
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Chapter and Conference Paper
Reduced Level of Philadelphia Chromosome Positive (Ph+) Cells in Lineage Negative Side Population Bone Marrow Progenitor Cells from Patients with Chronic Myeloid Leukemia (CML)
Recent reports have identified CD34neg normal hematopoietic stem cells from several species based on their Hoechst 33342 dual emission staining profile. Side population (SP) cells exclude Hoechst 33342 (Hoechstlo...
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Chapter and Conference Paper
Uncoupling of the β2-Adrenoceptor Effect on Ca2+ Regulation and cAMP in Cardiac Cells
Studies in rat ventricular myocytes demonstrate that while both β1-adrenergic receptor stimulation (β1ARS) and β2AR stimulation (β2ARS) increase cyclic adenosine monophosphate (cAMP) to a similar extent, the effe...
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Chapter and Conference Paper
Preliminary Histomorphometric Study on Pathological Grading of Giant Cell Tumors of Bone
Since Jaffe and his associates [1, 2], emphasized the importance of histological grading of giant cell tumor (GCT) of bone and classified them into three grades, benign or low aggressive, more aggressive or ma...