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  1. No Access

    Chapter and Conference Paper

    Evaluation of Betulinic Acid Derivatives as PET Tracers for Hypoxia-Induced Carbonic Anhydrase IX (CA IX) Expression

    Non-invasive visualisation of the expression of hypoxia-related proteins, such as carbonic anhydrase IX (CA IX), by positron emission tomography (PET) could provide important information on the oxygenation sta...

    V. Haupt, D. Gündel, E. Prell, M. Kahnt, S. Sommerwerk… in Oxygen Transport to Tissue XLIII (2022)

  2. No Access

    Chapter and Conference Paper

    Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo

    Extracellular acidosis is a characteristic of solid tumours, resulting from hypoxia-induced glycolytic metabolism as well as from the “Warburg effect” (aerobic glycolysis). The acidic environment has shown to ...

    M. Rauschner, S. Reime, A. Riemann, O. Thews in Oxygen Transport to Tissue XLIII (2022)

  3. No Access

    Chapter and Conference Paper

    Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells

    Signalling pathways such as ERK1/2, p38 or PI3K are activated in tumour cells by extracellular acidosis, which is a common phenomenon in human tumours. These signalling pathways can modulate the mitochondrial ...

    C. Degitz, S. Reime, O. Thews in Oxygen Transport to Tissue XLIII (2022)

  4. No Access

    Chapter and Conference Paper

    Role of the mTOR Signalling Pathway During Extracellular Acidosis in Tumour Cells

    The metabolic microenvironment of solid tumours is often dominated by extracellular acidosis which results from glycolytic metabolism. Acidosis can modulate gene expression and foster the malignant progression...

    M. Wolff, M. Rauschner, S. Reime, A. Riemann, O. Thews in Oxygen Transport to Tissue XLIII (2022)

  5. No Access

    Chapter and Conference Paper

    Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility

    The tumor microenvironment is characterized by hypoxia, acidosis as well as other metabolic and biochemical alterations. Its role in cancer progression is increasingly appreciated especially on invasive capaci...

    A. Riemann, B. Schneider, D. Gündel, C. Stock… in Oxygen Transport to Tissue XXXVII (2016)

  6. No Access

    Chapter and Conference Paper

    Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells

    Hypoxia and extracellular acidosis are common features of solid malignant tumors. The aim of the study was to analyze whether these pathophysiological parameters affect the expression of inflammatory mediators...

    A. Riemann, A. Ihling, S. Reime, M. Gekle, O. Thews in Oxygen Transport to Tissue XXXVIII (2016)