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  1. No Access

    Chapter and Conference Paper

    Toxicity of the Progestagen STS 557 Compared to Levonorgestrel in Beagles After Oral Administration for 6 Months

    Female and male beagle dogs were administered orally STS 557 (17α-cyanomethyl-17β-hydroxy-13β-methyl-gon-4,9(10)-dien-3-one) for 6 months at dose levels of 0.01, 0.1, or 1.0 mg/kg/day, and levonorgestrel at a dos...

    H. G. Hillesheim, H. Hoffmann, J. Güttner, M. Oettel in New Toxicology for Old (1982)

  2. No Access

    Chapter and Conference Paper

    Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA

    Prolonged estrogen treatment induced an enlargement of the anterior pituitary gland and finally resulted in irreversible pituitary tumours.

    M. Koch, M. Oettel, H. Lauterbach, H. Freund in Further Studies in the Assessment of Toxic… (1980)

  3. No Access

    Chapter and Conference Paper

    Lysozyme (Muramidase) and Hemolytic Complement (CH50U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens

    In studies for the chronic toxicity of estrogens and gestagens, lysozyme and hemolytic complement (CH50U) in sera of beagle dogs and minipigs were measured. Various doses of the sexsteroids were given: 0.01 mg, 0...

    A. Stelzner, G. Klinger, M. Oettel… in Further Studies in the Assessment of Toxic… (1980)

  4. No Access

    Chapter and Conference Paper

    Embryotoxic Effects of Post-Coital Fertility Inhibiting Steroids

    In mice post-coital estrogens caused retardation of tubal egg cleavage, whereas post-coital progestins stimulated egg division. In rats the situation was reversed. In this species estrogens accelerated the tub...

    M. Oettel, A. Kurischko, J. Strecke, M. Koch in Further Studies in the Assessment of Toxic… (1980)