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Chapter and Conference Paper
Toxicity of the Progestagen STS 557 Compared to Levonorgestrel in Beagles After Oral Administration for 6 Months
Female and male beagle dogs were administered orally STS 557 (17α-cyanomethyl-17β-hydroxy-13β-methyl-gon-4,9(10)-dien-3-one) for 6 months at dose levels of 0.01, 0.1, or 1.0 mg/kg/day, and levonorgestrel at a dos...
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Chapter and Conference Paper
Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA
Prolonged estrogen treatment induced an enlargement of the anterior pituitary gland and finally resulted in irreversible pituitary tumours.
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Chapter and Conference Paper
Lysozyme (Muramidase) and Hemolytic Complement (CH50U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens
In studies for the chronic toxicity of estrogens and gestagens, lysozyme and hemolytic complement (CH50U) in sera of beagle dogs and minipigs were measured. Various doses of the sexsteroids were given: 0.01 mg, 0...
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Chapter and Conference Paper
Embryotoxic Effects of Post-Coital Fertility Inhibiting Steroids
In mice post-coital estrogens caused retardation of tubal egg cleavage, whereas post-coital progestins stimulated egg division. In rats the situation was reversed. In this species estrogens accelerated the tub...