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    Chapter and Conference Paper

    Structure-Guided Deimmunization of Therapeutic Proteins

    Therapeutic proteins continue to yield revolutionary new treatments for a growing spectrum of human disease, but the development of these powerful drugs requires solving a unique set of challenges. For instanc...

    Andrew S. Parker, Karl E. Griswold… in Research in Computational Molecular Biology (2012)

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    Chapter and Conference Paper

    Optimization of Combinatorial Mutagenesis

    Protein engineering by combinatorial site-directed mutagenesis evaluates a portion of the sequence space near a target protein, seeking variants with improved properties (stability, activity, immunogenicity, e...

    Andrew S. Parker, Karl E. Griswold… in Research in Computational Molecular Biology (2011)

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    Chapter and Conference Paper

    Protein Fragment Swap**: A Method for Asymmetric, Selective Site-Directed Recombination

    This paper presents a new approach to site-directed recombination, swap** combinations of selected discontiguous fragments from a source protein in place of corresponding fragments of a target protein. By be...

    Wei Zheng, Karl E. Griswold… in Research in Computational Molecular Biology (2009)