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Survey of Enzymological Data on ODCase
OMP decarboxylase (ODCase) has been the subject of enzymological, structural, and theoretical studies for several decades, yet its highly proficient...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Crystallographic Studies of Native and Mutant Orotidine 5′phosphate Decarboxylases
This review aims to use the results of an approach combining crystallographic structure analysis with mutational studies as a framework for the...
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Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
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What Has Theory and Crystallography Revealed About the Mechanism of Catalysis by Orotidine Monophosphate Decarboxylase?
In 1995, Wolfenden and Radzicka showed that orotidine 5′-monophosphate decarboxylase (ODCase) was the most proficient enzyme. Since then, the...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
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Catalysis by Enzyme Conformational Change
An energy decomposition scheme is presented to elucidate the importance of the change of protein conformation substates to the reduction of...
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Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
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Insight into the Catalytic Mechanism of Orotidine 5′-phosphate Decarboxylase from Crystallography and Mutagenesis
With a half-time of 78 million years at room temperature, the spontaneous decarboxylation of orotidine 5′-phosphate (OMP) is among the slowest...
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Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
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Regulating membrane curvature
Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle...
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Phosphoinositides and membrane traffic in health and disease
The phosphorylated derivatives of phosphatidylinositol (PtdIns) are collectively known as the polyphosphoinositides (PIs) and they were originally...
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Develo** Active Site Models of ODCase—from Large Quantum Models to a QM/MM Approach
The catalytic mechanism of orotidine monophosphate decarboxylase (ODCase) has been modeled using density functional theory with the B3LYP functional....
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The function of Sec1/Munc18 proteins – Solution of the mystery in sight?
Members of the Sec1/Munc18 (SM) protein family form a central part of the machinery responsible for transport vesicle docking and fusion. Their...
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Medicinal Plants in the Tropics Used in the Treatment and Management of Parasitic Diseases Transmitted by Mosquitoes: Administration, Challenges, and Strategic Options for Management
Mosquitoes are highly diversified insect group, globally distributed, and carry and transmit parasitic infections that are recognized threats to the...
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Medicinal Spice, Aframomum melegueta: An Overview of the Phytochemical Constituents, Nutritional Characteristics, and Ethnomedicinal Values for Sustainability
This chapter explores the botanical characteristics, traditional uses, culinary applications, and medicinal properties of the medicinal spice,...
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Citrus aurantium: Phytochemistry, Therapeutic Potential, Safety Considerations, and Research Needs
Citrus aurantium, commonly referred to as sour orange or bitter orange, holds significant importance both in biological and economic terms....
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Cola accuminata: Phytochemical Constituents, Nutritional Characteristics, Scientific Validated Pharmacological Properties, Ethnomedicinal Uses, Safety Considerations, and Commercial Values
The tropical plant Cola accuminata, more often known as Cola nut, has a long history of traditional and ethno-medical applications. Our discussions...
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Garcinia kola Heckel. (Clusiaceae): An Overview of the Cultural, Medicinal, and Dietary Significance for Sustainability
This chapter aims to discuss the cultural, medicinal, and dietary significance of Garcinia kola Heckel (Clusiaceae) from a sustainability standpoint....