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Radiosensitizers in the Era of Immuno-Oncology
Radiation treatment is known to have immunomodulatory effects that contribute to its therapeutic efficacy. With the introduction and approval of...
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Targeting the DNA Damage Response for Radiosensitization
Radiation is a DNA-damaging agent that exerts its lethal anti-tumoral effects predominately by inducing DNA double-strand breaks. Tumor cells can...
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Normalizing the Tumor Microenvironment for Radiosensitization
Radiation is used in various cancer treatment regimens. However, hypoxia—a hallmark of the tumor microenvironment (TME)—drives disease progression...
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Translating Targeted Radiosensitizers into the Clinic
Radiation therapy is commonly used in the curative treatment of cancer. Despite recent progress in the techniques of radiation delivery and...
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Mechanisms and Markers of Clinical Radioresistance
Predictive biomarkers that allow rational selection of treatments for individual patients have played a central role in precision oncology. While...
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Preclinical Strategies for Testing of Targeted Radiosensitizers
Use of radiation for cancer therapy began shortly after the discovery of X-rays in 1895. Technological advances over the ensuing 120 years have...
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Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
Genetically engineered mouse models (GEMMs) are powerful research tools that have improved our understanding of cancer and enabled the identification...
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Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges
The practice of radiation oncology is currently primarily based on precise technical delivery of highly conformal, image-guided radiation treatments....
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Targeting Tumor Metabolism to Overcome Radioresistance
Metabolic reprogramming is a hallmark of cancer. Altered metabolism provides a survival advantage for cancer cells during tumorigenesis by supplying...
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Map** the Radiogenome of Human Cancers
Precision oncology enables individualized treatment decisions on the basis of patient - and tumor-specific features. Despite growing evidence that...
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3D Radiation Biology for Identifying Radiosensitizers
The development and clinical implementation of novel therapeutics for the improvement of cancer patient survival is based on innovative and...
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Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments
Over the past several years, significant technological and biological progress has been made in radiation oncology with focus on the development of...
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Targeting Tumor Hypoxia
Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The development of tumor hypoxia can be viewed as an imbalance between oxygen...
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Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy
Radiotherapy is a commonly used local and regional treatment for cancer. Although important advances in radiation treatment delivery have been made...
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Application of Functional Molecular Imaging in Radiation Oncology
Molecular imaging of tumors is rapidly gaining momentum as a tool with the capacity to improve cancer treatment. It has the potential to provide more...
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Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity
The advent of the modern era of molecularly targeted therapies in oncology has generated considerable excitement in the field of oncology. While...
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Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules
The use of hypofractionated regimens for the treatment of tumors with radiation has come full circle. After the discovery of X-rays and their...
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Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology?
With the recognition that the host and tumor are inextricably intertwined as a malignant system, the tumor microenvironment (TME) is now considered...
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Novel Imaging for Treatment Planning or Tumor Response
Anatomic imaging has long represented an integral part of modern radiotherapy, from planning, image-guidance to response evaluation. Functional...
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Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles
Nanoparticles have garnered significant interest in recent decades for both biomedical imaging and therapeutic applications. The ability to finely...