10 Result(s)
within
Chapter
Yan **ng
Biomedicine
Biomedicine, general
Medicine/Public Health, general
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Chapter
Sphingosine 1-Phosphate Metabolism and Signaling
Sphingosine 1-phosphate (S1P) is a well-defined bioactive lipid molecule derived from membrane sphingolipid metabolism. In the past decades, a series of key enzymes involved in generation of S1P have been iden...
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Rare Diseases in Glycosphingolipid Metabolism
Sphingolipidoses is a cluster of genetic rare disorders regarding glycosphingolipid metabolism, classified as lysosomal storage disorders (LSD). Here, we focus on eight inheritable diseases, including GM1 gang...
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Autophagy and Lymphoma
Lymphoma is a hematological malignancy and its incidence is growing. The use of CD20 monoclonal antibody improves the therapeutic efficacy in CD20-positive B-cell lymphoma. Despite remarkable progress in lymph...
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Autophagy, Myocarditis, and Cardiomyopathy
Direct damage and immune responses after viral infection lead to myocarditis. Autophagy is involved in both viral clearance and replication. In this chapter, we will briefly describe the role of autophagy in v...
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Autophagy and Tumor Cell Death
There exists an intricate collaboration between autophagy and other types of PCD. These processes can be activated in parallel or sequentially, and have either common or opposite objectives. Determining which ...
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Autophagy and Leukemia
Leukemia is a malignant clonal disease that originates from hematopoietic stem cells. As in-depth research examines the molecular biology and immunology of the hematopoietic system, leukemia treatment has evol...
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Autophagy and Myeloma
Multiple myeloma is a hematological malignancy. It is characterized by the abnormal clonal proliferation of malignant plasma cells in the bone marrow and the secretion of a large number of monoclonal immunoglo...
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Autophagy and Heart Failure
Pressure overload can lead to cardiac hypertrophy and heart failure. Autophagic activity could be detected in heart failure patients and animal models. However, the role of autophagy in heart failure is not cl...
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Exosomes as Vehicles for Systemic Drug Delivery
Naturally occurring compounds (e.g., lipids and proteins) can serve as constituents for carrier production; biological entities per se may also function as ready-made carriers for systemic delivery. Examples o...
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Autophagy and Tumorigenesis
Tumour cells are derived from normal cells that undergo numerous genetic and epigenetic mutations under various stresses. This process involves changes in many intrinsic cellular mechanisms and in the microenv...
