28 Result(s)
within
Chapter
Wei WANG
Life Sciences
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Chapter
Application of CRISPR-Cas-Based Genome Editing for Precision Breeding in Wheat
Wheat improvement relies on genetic diversity associated with variation in target traits. While traditionally the main sources of novel genetic diversity for breeding are wheat varieties or various wild relati...
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Glycosylation Profiling as a Biomarker of Suboptimal Health Status for Chronic Disease Stratification
WHO defines health as “a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.” We coined and defined suboptimal health status (SHS) as a subclinical, re...
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Crop Information Sensing Technology
Precision agricultural practice requires getting aware of crop growth situation via sensitive, accurate, economical, and fast sensing means to improve decision-making for production management. Supported by Io...
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Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa (RP): Retinal Cell-Based Therapy
The major cause of hereditary blindness in North America is retinitis pigmentosa (RP), which is a group of inherited retinal diseases characterized by the onset of night blindness, early loss of peripheral vis...
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Surface Absorption of 137Cs Through Tree Bark
Bark–wood translocation has been suggested as an important route for the contamination of trees via radiocesium in the initial stage of deposition. We investigated cesium absorption through the bark of Japanes...
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Space Radiation Systems Biology Research in SJ-10 Satellite
Space radiation biology is one of the important parts of space biology, mainly focusing on the mechanisms of biological effects and genetic variations in organisms induced by space radiation. Space radiation b...
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Purification of Fluorescent Labeled Cells from Dissociated Ciona Embryos
Genome-wide studies in Ciona often require highly purified cell populations. In this methods chapter, we introduce multi-channel combinatorial fluorescence activated cells sorting (FACS) and magnetic-activated ce...
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Imaging and Tracking Transplanted Bone Marrow Stem Cells After Stroke
Stem cells provide a promising therapy for treating stroke. Several imaging techniques provide the possibility of the visual representation of biological processes of transplanted stem cells in vivo. Further m...
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Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction
Ubiquitination is a highly conserved post-translational modification in eukaryotes, well known for targeting proteins for degradation by the 26S proteasome. Proteins destined for proteasomal degradation are se...
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Proteomics Driven Research of Abiotic Stress Responses in Crop Plants
Wheat, maize (Zea mays L.), and rice are the most grown cereal crop plants worldwide. Abiotic stresses (primarily caused by drought, salinity, high and low temperatures, etc.) negatively affect crop plant growth,...
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The Response of Chloroplast Proteome to Abiotic Stress
The chloroplast is a typical plant organelle in plant cells, which is mainly responsible for photosynthesis as well as other essential functions. The chloroplast has gained considerable attention due to its in...
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Proteomics in Sex Determination of Dioecious Plants
Sex determination in plants is controlled by complex endogenous genetic programs and responses to environmental cues. The great majority of the world’s flowering plants are hermaphrodite, while approximately 6...
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Targeting Cancer Metabolisms
Cancer cells have a different pattern of metabolism compared with that of normal differentiated adult cells. They mainly produce energy in the form of ATP through glycolysis, even in an oxygen-rich condition. ...
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Finding High-Order Correlations in High-Dimensional Biological Data
In many emerging real-life problems, the number of dimensions in the data sets can be from thousands to millions. The large number of features poses great challenge to existing high-dimensional data analysis m...
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Chapter and Conference Paper
Exploring Multi-layer Graphene Nanoribbon Interconnects
In this paper, an improvement of the existing conductance model for the single-layer GNR and a novel conductance model for multi-layer GNR are introduced. The models leverage the recent theoretical and theoret...
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Chapter and Conference Paper
3D CMOL Crossnet for Neuromorphic Network Applications
In this work, a novel 3D CMOL crossnet structure is introduced by combining two leading technological concepts for future nanoelectronic neuromorphic networks: CMOL crossnet and 3D integration. By implementing...
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Chapter and Conference Paper
FPAA Based on Integration of CMOS and Nanojunction Devices for Neuromorphic Applications
In this paper, a novel field programmable analog arrays (FPAA) architecture, namely, NueroFPAA, is introduced to utilize nanodevices to build a programmable neuromorphic system. By using nanodevices as program...
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Chapter and Conference Paper
COE: A General Approach for Efficient Genome-Wide Two-Locus Epistasis Test in Disease Association Study
The availability of high density single nucleotide polymorphisms (SNPs) data has made genome-wide association study computationally challenging. Two-locus epistasis (gene-gene interaction) detection has attrac...
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Chapter and Conference Paper
Triptolide Alters Mitochondrial Functions
Triptolide (TPL), a small molecule purified from the herb Tripterygium wilfordii, has potential clinical application for suppression of chronic autoimmune disorders and inhibition of tumor growth. However, its me...
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Chapter and Conference Paper
Anti-Cancer Effect of Resveratrol is Associated with Induction of Apoptosis via a Mitochondrial Pathway Alignment
Resveratrol, a phytoalexin found in the skin of grapes, is believed to have multiple bioactivities including anti-cancer, anti-carcinogenesis and antiinflammatory. The mechanisms by which resveratrol might pro...
