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Site-Directed Mutagenesis of Residues in the Active Site of Sepiapterin Reductase
Tetrahydrobiopterin (BH4) is the natural cofactor for producing neurotransmitters such as catecholamines, indoleamines, and nitric oxide. Sepiapterin reductase (SPR; EC 1. 1. 1. 153) catalyzes the terminal step i...