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    Site-Directed Mutagenesis of Residues in the Active Site of Sepiapterin Reductase

    Tetrahydrobiopterin (BH4) is the natural cofactor for producing neurotransmitters such as catecholamines, indoleamines, and nitric oxide. Sepiapterin reductase (SPR; EC 1. 1. 1. 153) catalyzes the terminal step i...

    K. Fujimoto, T. Nonaka, M. Sakurai, S. Katoh in Chemistry and Biology of Pteridines and Fo… (2002)