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    Chapter

    Human In Vitro Blood-Brain Barrier Models Derived from Stem Cells

    In vitro blood-brain barrier (BBB) models have significant utility in understanding the BBB in health and disease. While human BBB models using primary and immortalized brain endothelial cells have been descri...

    Koji L. Foreman, Sean P. Palecek, Eric V. Shusta in Drug Delivery to the Brain (2022)

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    Chapter

    High-Throughput Screening, Microfluidics, Biosensors, and Real-Time Phenoty**

    Key opportunities for the field of stem cell engineering involve identification of cues that regulate stem cell fate, constructing a systems level understanding of how cells sense and process information provi...

    Sean P. Palecek in Stem Cell Engineering (2014)

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    Chapter

    Characterizing International Stem Cell Research Niches

    Regenerative medicine has evolved differently in global regions, in part due to policies and funding patterns but also due to their styles of governance within particular historical and political conditions. I...

    Linda F. Hogle, Sean P. Palecek, David Schaffer in Regenerative Medicine Ethics (2014)

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    Chapter

    Biomanufacturing Human Pluripotent Stem Cells for Therapeutic Applications

    Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs) can be propagated indefinitely and have the potential to differentiate to all cell types of the body. In addition, patient-sp...

    **aojun Lian, Sean P. Palecek in Advances in Stem Cell Research (2012)

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    Chapter and Conference Paper

    Differentiation of Human Embryonic Stem Cells Encapsulated in Hydrogel Matrix Materials

    Prior work on many cell types, including stem cells, has definitively shown that mechanical stiffness of the neighboring material and the overall stress state influences cell behavior. There is also evidence t...

    Max Salick, Richard A. Boyer, Chad H. Koonce in Experimental and Applied Mechanics, Volume… (2011)

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    Chapter

    Pluripotent Stem Cells: Sources and Characterization

    Pluripotent human stem cells, including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, hold tremendous promise as a source of progenitor cells and terminally differentiated cells in tissue...

    Sean P. Palecek in Tissue Engineering (2011)