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Chapter
Human In Vitro Blood-Brain Barrier Models Derived from Stem Cells
In vitro blood-brain barrier (BBB) models have significant utility in understanding the BBB in health and disease. While human BBB models using primary and immortalized brain endothelial cells have been descri...
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Chapter
High-Throughput Screening, Microfluidics, Biosensors, and Real-Time Phenoty**
Key opportunities for the field of stem cell engineering involve identification of cues that regulate stem cell fate, constructing a systems level understanding of how cells sense and process information provi...
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Chapter
Characterizing International Stem Cell Research Niches
Regenerative medicine has evolved differently in global regions, in part due to policies and funding patterns but also due to their styles of governance within particular historical and political conditions. I...
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Chapter
Biomanufacturing Human Pluripotent Stem Cells for Therapeutic Applications
Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs) can be propagated indefinitely and have the potential to differentiate to all cell types of the body. In addition, patient-sp...
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Chapter and Conference Paper
Differentiation of Human Embryonic Stem Cells Encapsulated in Hydrogel Matrix Materials
Prior work on many cell types, including stem cells, has definitively shown that mechanical stiffness of the neighboring material and the overall stress state influences cell behavior. There is also evidence t...
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Chapter
Pluripotent Stem Cells: Sources and Characterization
Pluripotent human stem cells, including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, hold tremendous promise as a source of progenitor cells and terminally differentiated cells in tissue...