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    Chapter and Conference Paper

    PREMER: Parallel Reverse Engineering of Biological Networks with Information Theory

    A common approach for reverse engineering biological networks from data is to deduce the existence of interactions among nodes from information theoretic measures. Estimating these quantities in a multidimensi...

    Alejandro F. Villaverde, Kolja Becker in Computational Methods in Systems Biology (2016)

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    Chapter and Conference Paper

    Optimization Based Design of Synthetic Oscillators from Standard Biological Parts

    We consider the problem of optimal design of synthetic biological oscillators. Our aim is, given a set of standard biological parts and some pre-specified performance requirements, to automatically find the ci...

    Irene Otero-Muras, Julio R. Banga in Computational Methods in Systems Biology (2014)

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    Chapter and Conference Paper

    Improved Parameter Estimation in Kinetic Models: Selection and Tuning of Regularization Methods

    Kinetic models are being increasingly used as a systematic framework to understand function in biological systems. Calibration of these nonlinear dynamic models remains challenging due to the nonconvexity and ...

    Attila Gábor, Julio R. Banga in Computational Methods in Systems Biology (2014)

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    Chapter and Conference Paper

    On the Verification and Correction of Large-Scale Kinetic Models in Systems Biology

    In this paper we consider the problem of verification of large dynamic models of biological systems. We present syntactical criteria based on biochemical kinetics to ensure the plausibility of a model and the ...

    Attila Gábor, Katalin M. Hangos in Computational Methods in Systems Biology (2013)