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    Chapter

    Marine Natural Products and their Synthetic Derivatives for Cancer Therapy

    The ocean, which covers approximately 70% of the Earth’s surface, is a natural treasury of resources that houses about 80% of all the varieties of life on our planet. The past 20 years have seen a decrease in ...

    Tao Jiang, Puyong Zhang, Shaopeng Chen… in Alternative and Complementary Therapies fo… (2010)

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    Chapter

    Mining Natural Product-Derived Molecules Against Cancer Targets: The Case of the Androgen Receptor in Prostate Cancer

    Androgen receptor (AR) signaling is critical for prostate cancer progression. This has provided the rationale for the use of androgen ablation therapy, involving either surgical or chemical castration, to redu...

    Jian Hui Wu in Alternative and Complementary Therapies for Cancer (2010)

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    Chapter

    Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation

    One of the most intensively studied non-genotoxic carcinogens is the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). Since TPA appears to exert its biologic effects through protein kinase...

    Kevin R. O’Driscoll, Scott M. Kahn… in Oncogene and Transgenics Correlates of Can… (1992)