56 Result(s)
within
English
Biomedicine
Oncology
Jian** **
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Significance of FUT8 in Pancreatic Cancer and Others
Abnormal changes in glycosylation have been positively correlated with tumorigenesis and progression in cancer. In particular, an elevation in the level of core fucosylation has been observed. Core fucosylatio...
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Superior Vena Cava Syndrome
The superior vena cava syndrome (SVCS) involves a group of symptoms deriving from obstruction or compression of the superior vena cava. Malignant causes represents the m...
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Biological Response Modifier in Cancer Immunotherapy
Biological response modifiers (BRMs) emerge as a lay of new compounds or approaches used in improving cancer immunotherapy. Evidences highlight that cytokines, Toll-like receptor (TLR) signaling, and noncoding...
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Adoptive Cellular Therapy (ACT) for Cancer Treatment
Adoptive cellular therapy (ACT) with various lymphocytes or antigen-presenting cells is one stone in the pillar of cancer immunotherapy, which relies on the tumor-specific T cell. The transfusion of bulk T-cel...
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Stemness Regulation of Somatic Cancer Cells
Embryonic stem (ES) cells derive from the inner cell mass (ICM) of the blastocyst in early embryo stage, which lasts only a few days during the life. Soon after the blastocyst implants in endometrium, ICM cell...
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Radiosurgery for Intramedullary Spinal Cord Tumors
Intrinsic intramedullary spinal cord tumors (ISCTs) account for 8–10 % of all primary spinal cord tumors, while intramedullary spinal cord metastases (ISCMs) account for less than 5 % of all spinal tumors. Whi...
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The ROCK Signalling Pathway and Tight Junctions
An important step in the formation of cancer metastases is penetration of the vascular endothelium by dissociated cancer cells. Epithelial cell-cell contacts consist of three main adhesive structures: tight ju...
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VEGF-Mediated Effects on Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across the Blood-Brain Barrier
Breast cancer spreads to the bones, lungs, brain and liver. While the mechanisms of breast metastasis to bones and lungs have been studied and characterized, there is little information about the molecular bas...
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Tight Junctions in Human Urinary Bladder Cancer
The majority of patients, who die from bladder cancer, ultimately do so from metastasis. A breakdown in the cell-cell bond seems likely to occur both, between cancer cells for tumour migration and between urot...
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Validity of Markers for Epithelial Cells and Mesenchymal Cells
Stem cells are best known for their potential of differentiation. However, those so-called differentiated cells are not exactly lack of plasticity. This can be easily seen during wound healing, in which a lot ...
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Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy
Conquering cancer, one of the leading human health problems, is a major task for both basic and clinical scientists. With the understanding of recently developed cancer immunotherapy, in particular the cytotox...
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Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells
Evaluation of the impact of traditional medicine on cancer cells has been challenging, for many reasons including challenges to obtain suitable cell models and reliable and predictive methods. This brief chapt...
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Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents
As one of the earliest matured techniques for in vitro cell migration study in wound healing, traditional scratch assay has been routinely utilized due to its simplicity of setup in cell culture. However, with th...
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Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses
Interaction between tumour cells and endothelial cells is an essential step during the systemic step of cancer metastasis in the body and has been an active area pursued for the past decades. However, methods ...
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Mesenchymal Stem Cells and Mesenchymal-Derived Endothelial Cells: Repair of Bone Defects
It is a major clinical challenge for reconstructive surgeons to repair the bone defects caused by trauma, infection, tumor resection and other reasons. Bone tissue engineering is a promising method for repairi...
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Current and Future Applications of ECIS Models to Study Bone Metastasis
Bone metastasis is the most common type of metastasis from the three leading cancers, i.e. prostate, breast and lung cancer. Over the last few decades, intensive studies have been carried out to understand and...
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ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN)
Metastasis is a major determining factor in the clinical outcome of cancer patients and accounts for the vast majority of cancer mortality. The process through which cancer cells metastasise is complex, requir...
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ECIS, Cellular Adhesion and Migration in Keratinocytes
Evaluation of keratinocyte adhesion and migration using ECIS, as will be shown below, is predominantly used to study the effects of various genes, proteins and molecules on wound healing. Keratinocytes underta...
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Epithelial-Mesenchymal Transition and the Use of ECIS
The development of tumour cell invasion and metastasis is a prime factor influencing prognosis of cancer patients. Understanding the mechanisms involved in tumour cell invasion may aid in limiting tumour progr...
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Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing)
Tight Junctions (TJ) control the paracellular diffusion of ions and certain molecules and it has become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ st...
