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Chapter
Hybrid Learning in Neurosurgery
Hybrid learning substitutes the process of in-person, face-to-face knowledge transfer with online learning. By exploiting connectivism in the digital era through the internet and social media platforms, novel ...
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Global Neurosurgery: How Best to Be Involved
In this chapter, Dr. Dewan and Dr. Rutka discuss involvement in neurosurgery on a global level. Education and training represent the most impactful means of combating the deficit in the provision of essential ...
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Dysembryoplastic Neuroectodermal Tumors
Dysembryoplastic neuroectodermal or neuroepithelial tumor (DNET) was initially described by Daumas-Duport et al. [1] in 1988 as a mixed tumor with glial and neuronal elements and has been included in the World...
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Chapter
Craniopharyngioma: Current Classification, Management, and Future Directions
Craniopharyngioma is one of the most challenging brain tumors, located in sellar/suprasellar region in close proximity to the optic apparatus and hypothalamus. Although histologically low grade, the tumor can ...
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Neurocutaneous Syndromes
Neurocutaneous disorders are a heterogeneous group of genetic disorders characterized by abnormalities of the skin and nervous systems due to their common embryological origin. These disorders have inconsisten...
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Brainstem Tumors in Children
Brainstem tumors are a disparate group of tumors that span the regions of the midbrain to the cervicomedullary junction (Fig. 20.1). They most frequently occur in children and lack a specific gender predilecti...
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Thalamic Gliomas
Pediatric thalamic gliomas present specific challenges in surgical and oncological management. Although the tumor histopathologies are similar to their supratentorial counterparts and are often benign, they ar...
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Neurosurgical Management of Pediatric Brain Tumors
The management of pediatric central nervous system neoplasms (CNS) poses a formidable challenge to clinicians. The purpose of this chapter is to provide a broad overview of commonly encountered neoplasms affli...
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Chapter
Dysembryoplastic Neuroectodermal Tumors
Dysembryoplastic neuroectodermal or neuroepithelial tumor (DNET) was initially described by Daumas-Duport et al. [5] in 1988 as a mixed tumor with glial and neuronal elements, and has been included in the Worl...
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Chapter
Medulloblastoma-PNET, Craniopharyngioma Adult Tumors of Pediatric Origin
According to the new WHO classification, embryonal tumors comprise medulloblastomas, primitive neuroectodermal tumors (PNET), medulloepitheliomas, ependymoblastomas, and neuroblastomas. We include here also cr...
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Chapter
Choroid Plexus Tumors
Choroid plexus tumors (CPTs) are rare, primary brain tumors arising from the neuroepithelium of the choroid plexus. Although they may be found in patients of any age, the vast majority occur in the pediatric p...
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Neurocutaneous Syndromes
The neurofibromatoses (NFs) encompass several disorders that have as common features both cutaneous pigmented lesions and tumors of neuroectodermal origin. Among this group, NF I and NF II are most common. NF ...
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Tumors of the Skull Base in Children
Tumors of the skull base present a difficult therapeutic challenge to the neurosurgeon because of the complexity involved in approaching these lesions. However, with recent technical advances and the developme...
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Pediatric Meningiomas
Pediatric meningiomas represent a unique challenge to the neurosurgeon, as they are somewhat uncommon and harbor unique clinical and pathologic characteristics [1]. While there is some debate about the definit...
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Recent Developments in the Molecular Biology of Human Brain Tumors
Many of the most important scientific achievements within the field of medicine have come to light within the past 40 years. Watson and Crick discovered the structure of DNA in 1952. The genetic code of the hu...
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The Extracellular Matrix: Cues from the Microcellular Environment Which Can Inhibit or Facilitate Glioma Cell Growth
The extracellular matrix (ECM) is the naturally occurring substrate upon which cells migrate, proliferate, and differentiate in vivo [1,2]. The ECM functions as a biological adhesive that maintains the normal cyt...