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  1. No Access

    Chapter and Conference Paper

    Use of Investigational Drugs as Initial Therapy for Childhood Solid Tumors

    Solid tumors are relatively rare in children, but comprise about two-thirds of all malignancies that affect this age group. Most of these tumors respond well to initial treatment, and some (Wilms’ tumor, low-s...

    W. H. Meyer, P. J. Houghton, M. E. Horowitz… in Modern Trends in Human Leukemia VIII (1989)

  2. No Access

    Chapter and Conference Paper

    Current Treatment and Results of St. Jude Studies for Childhood Acute Lymphoblastic Leukemia

    The Goldie-Coldman hypothesis predicts that early use of all active agents in maximum doses will increase leukemic cell kill and prevent the early emergence of drug resistance [1]. Results of contemporary clin...

    C.-H. Pui, G. K. Rivera, W. E. Evans, J. T. Sandlund, M. L. Hancock… in Acute Leukemias IV (1994)

  3. No Access

    Chapter and Conference Paper

    Risk-Adapted Treatment for Acute Lymphoblastic Leukemia: Findings from St. Jude Children’s Research Hospital

    Data from St. Jude Total Therapy Study XI were analyzed to identify clinical and biologic features with prognostic significance. Results of this analysis, along with information available in the literature, le...

    C.-H. Puil, G. K. Rivera, M. L. Hancock, J. T. Sandlund… in Acute Leukemias VI (1997)

  4. No Access

    Chapter and Conference Paper

    Pharmacodynamics in Childhood Acute Lymphoblastic Leukemia

    Pharmacokinetic variability clearly influences the outcome of treatment for acute lymphoblastic leukemia (ALL), but its utility as a clinical risk factor is limited when patients receive complex multiagent reg...

    Ching-Hon Pui, M. V. Relling, J. T. Sandlund, D. Campana… in Acute Leukemias VIII (2001)