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    TGF-β as Tumor Suppressor: Lessons from Mouse Models

    Transforming growth factor-β (TGF-β) signals through serine/threonine-kinase receptors to activate several intracellular signaling pathways, including the “canonical” Smad signaling pathway. TGF-β has tumor-su...

    Ulrich Valcourt, David F. Vincent, Laurent Bartholin in TGF-β in Human Disease (2013)

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    TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition

    Over time, TGF-β has emerged as both a tumor promoter and a tumor suppressor, depending on the cell type. Although it was first characterized as having the capacity to transform mesenchymal cells, many studies...

    Laurent Bartholin, David F. Vincent, Ulrich Valcourt in TGF-β in Human Disease (2013)