24 Result(s)
within
Life Sciences
Biomaterials
Biotechnology
Chemistry/Food Science, general
Immunology
Regenerative Medicine/Tissue Engineering
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Chapter
Mimicking Islet Development with Human Pluripotent Stem Cells
The development of functional beta cells from human pluripotent stem cells (PSCs) offers a promising approach for treating type 1 diabetes (T1D). However, current differentiation protocols often yield heteroge...
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Bioactive Materials for Use in Stem Cell Therapies for the Treatment of Type 1 Diabetes
Diabetes is a major challenge to healthcare providers globally, with significant human and financial costs. Type 1 diabetes is expected to effect more than a million people concurrently, with over 130,000 newl...
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Pancreatic Cell Fate Specification: Insights Into Developmental Mechanisms and Their Application for Lineage Reprogramming
Adult differentiated cells can be forced to switch identities from one cell type to another under the direction of specific transcription factors (TF) in so-called direct lineage reprogramming. The ability to ...
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Immunogenicity of Stem Cell Derived Beta Cells
One of the biggest challenges in beta cell replacement therapy of patients with type 1 diabetes relates to the cause of their disease: islet autoimmunity. The permanent immune suppressive therapy that is the c...
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The Promises of Pancreatic Progenitor Proliferation and Differentiation
Human pluripotent stem cells (hPSCs) have been proposed as an unlimited source of insulin-secreting pancreatic β cells for diabetes treatment. Many laboratories have demonstrated that hPSCs such as human embry...
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Islet Immunoengineering
From 2000 to 2020, 2170 patients globally received islet allotransplants. Islet transplantation into the hepatic portal vein seeks to replace the insulin-producing β cells that are lost to autoimmunity in type...
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Scaffolds for Encapsulation of Stem Cell-Derived β Cells
Currently, clinical islet transplantation is the most promising minimal invasive therapy to treat the most severe cases of type 1 diabetes, where exogenous insulin administration can no longer be used to contr...
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Genetic Safety Switches for Pluripotent Stem Cell-Derived Therapies for Diabetes
As human pluripotent stem cell (hPSC)-derived therapies move towards clinical application, ensuring the safety of transplanted cell populations remains a critical concern. Because undifferentiated hPSC are hig...
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Lessons Learned from Clinical Trials of Islet Transplantation
Islet of Langerhans transplantation has gained a clear place in the therapeutic armamentarium for type 1 diabetes and is now considered standard-of-care in many countries in which it is available. Depending on...
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3D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells
The scarcity of suitable pancreas/islet donors, the lifelong need for potentially toxic antirejection drugs for allogeneic islet transplants and several of the novel stem cell-based therapies, and the failure ...
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An Ethical Perspective on the Social Value of Cell-Based Technologies in Type 1 Diabetes
Regenerative medicine is set to revolutionize the treatment of type 1 diabetes. Using cell-based technologies, it seeks to restore within the patient’s body the function of pancreatic islets cells in regulatin...
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Clinical Trials with Stem Cell-Derived Insulin-Producing Cells
Because of the real-time physiological glucose sensing and synchronized insulin secretion, the replacement of β-cell mass through transplantation has long been recognized as an optimal treatment strategy for i...
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Extracellular Matrix to Support Beta Cell Health and Function
Primary islets or stem cell-derived islets (SC-islets) can be used in culture to study islet biology or can be clinically transplanted to reverse diabetes. However, islet survival and function is negatively af...
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Genetic Regulatory Networks Guiding Islet Development
The pancreatic islet is a mini-organ that consists of several hormone-secreting endocrine cell types in adults. Islets execute a vital physiological function in regulating glucose homeostasis, and endocrine ce...
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Islet Macroencapsulation: Strategies to Boost Islet Graft Oxygenation
Islet transplantation is a valid therapy for patients with type 1 diabetes. However, a widespread application is hampered by mandatory requirement of life-long immunosuppression, the shortage of cadaveric dono...
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Factors Influencing In Vivo Specification and Function of Endocrine Cells Derived from Pancreatic Progenitors
Pancreas cell fate specification has been well studied in mice but is less documented in humans due to the lack of availability of pancreas from different developmental stages. Human pluripotent stem cells (hP...
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Immune Evasive Stem Cell Islets
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-secreting β cells by the immune system (American Diabetes, A., Diabetes Care 32 Suppl 1:S62–67, 2009). It is characterized by...
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Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation
Type 1 diabetes is a life-threatening disease that is hallmarked by an autoimmune response against the insulin-producing β-cells in the pancreatic islets. Currently, clinical islet transplantation is the most ...
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Considerations Pertaining to Implant Sites for Cell-Based Insulin Replacement Therapies
Pancreatic islet transplantation (ITx) established proof of concept that cellular therapies are feasible options to manage intractable severe and recurrent hypoglycemia, but that they can also provide optimal ...
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Beta Cell Replacement Cellular Products: Emerging Regulatory Perspectives and Considerations for Program Development
In planning research programs for the development of cellular products for the replacement of pancreatic beta cells, it is critical at the outset to determine whether the work is intended to produce a marketab...
