5 Result(s)
within
Biomedicine
Immunology
Molecular Medicine
**na Hong
Chapter
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Chapter
Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection
Somatic mutations are the cornerstone of cancer (Hanahan et al. 2000). The development of cancer involves the contributions of many heritable genetic events as well as of a large number of epigenetic changes, ...
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Chapter
Small-molecule Hsp90 Inhibitors: Applications in Cancer and Neurodegenerative diseases
Hsp90 is a pleiotropic cytoplasmic chaperone that regulates an ever-growing list of client proteins. Hsp90 clients include many, but not all, kinases, steroid receptors and a number of transcription factors. M...
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Chapter and Conference Paper
Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers
An evolution in radiotherapy practice is leading to greater use of stereotactic body radiotherapy (SBRT), raising the prospect of increased hypoxic cell radioresistance. New clinical interest in nitroimidazole...
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Chapter
Microbial Factors in Inflammatory Diseases and Cancers
The intestinal microbes form a symbiotic relationship with their human host to harvest energy for themselves and their host and to shape the immune system of their host. However, alteration of this relationshi...
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Chapter
Autophagy in Plant Immunity
The highly conserved catabolic process of autophagy delivers unwanted proteins or damaged organelles to vacuoles for degradation and recycling. This is essential for the regulation of cellular homeostasis, str...
