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    Chapter

    The Internalization and Intracellular Trafficking of ADCs

    Internalization is thought to be an important process during the antibody-based therapeutics. As ADC internalizes, it is transported to lysosome for degradation and payload is released to target intracellular ...

    Keying Liang, M. Saleem Khan, M. Kalim… in Antibody-Drug Conjugates and Cellular Meta… (2023)

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    Chapter

    Antibody-Drug Conjugates: Basic Concepts and Structures

    Antibody-drug conjugates (ADCs) are new modality of anticancer therapeutics. To enhance the translation, three components of an ADC drug—antibody, linker, and cytotoxin— need to be carefully optimized. The sel...

    **biao Zhan in Antibody-Drug Conjugates and Cellular Metabolic Dynamics (2023)