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    Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

    Oncogenes, tumor suppressor genes, and apoptosis-inducing genes play critical roles in cell proliferation, differentiation, and death. Their expressions are frequently altered in cancer cells by gene mutation,...

    Lidong Zhang MD, PhD, Bingliang Fang MD, phD in Gene Therapy for Cancer (2007)

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    Chapter

    Adenovector-Mediated Cancer Gene Therapy

    Early-region (E1)-deleted, replication-defective adenovectors have been widely used in preclinical and clinical studies of cancer gene therapy. Recently, the use of conditional replicating or oncolytic adenove...

    Bingliang Fang MD, PhD, Jack A. Roth MD in Gene Therapy for Cancer (2007)

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    Chapter

    Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers

    Research has demonstrated that delivery of genes encoding tumor necrosis factor (TNF)-α, Fas ligand (FasL), and TNF-related apoptosis-inducing ligand (TRAIL) to tumors can elicit apoptosis in cancer cells and ...

    Lidong Zhang MD, Bingliang Fang MD in Death Receptors in Cancer Therapy (2005)