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117 Result(s)
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Chapter
Epigenetic Epidemiology of Cancer
The epigenome has been proposed as a biosensor of past or cumulative exposures and could also be a disease mediator. Human cancers exhibit a wide range of epigenetic alterations characterized by progressive ac...
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Chapter
Zinc Signals in Biology
Zinc is an essential nutrient that is required for the structure and catalytic activity of many different proteins. In addition to its well-established role as a cofactor, a growing amount of evidence suggests...
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Chapter
Sialoside Arrays: New Synthetic Strategies and Applications
Sialic acid-containing carbohydrates, or sialosides, play critical roles in many biological events and in diseases, including viral and bacterial infections, the immune response, the progression of tumor cell ...
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Chapter
Cancer Prevention by Different Forms of Tocopherols
Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α...
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Chapter
Production of Cellulases by Aspergillus sp. GDX02 in a Solid-State Fermentation Using Oil Palm Empty Fruit Bunch
A reduction in enzyme cost is one of the important factors for making bioethanol production more economically feasible. To this aim, we isolated a fungus, GDX02, to produce cellulases using agricultural wastes...
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Chapter
Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress
Epidermal growth factor receptor (EGFR) dysregulation drives several human pathological conditions, such as glioblastoma and non-small cell lung cancer, and as a result, EGFR activation, internalization, and d...
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Chapter and Conference Paper
Detection of the Primo Vessels in the Rodent Thoracic Lymphatic Ducts
Since Hippocrates described the anatomy of the blood and the lymphatic systems for the first time at BC400, these two vascular systems have been believed to be the only circulatory systems existing and operati...
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Chapter
Involvement of S-Nitrosylation in Neurodegeneration
S-nitrosylation is a post-translational modification that is found to regulate increasing number of cellular and physiological functions such as neurotransmission, vesicle trafficking, gene expression and apop...
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Chapter and Conference Paper
Synthesis of Hemagglutinin-Binding Trisaccharides
Influenza or the flu, caused by RNA influenza viruses, is an infectious disease that affects birds and mammals, including millions of people each year. It causes severe respiratory illness and is sometimes fat...
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Chapter
Protein–Nanodiamond Complexes for Cellular Surgery
Nanodiamonds have attracted great attentions lately for their superb physical/chemical properties and promising bio/medical applications. This versatile material in its nanoscale exhibits little cytotoxicity i...
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Chapter
Ion Channels with Mechanosensitivity in the Nervous System
Although sensation of the physical touch is the most ancient sense of all, our understanding is very scarce. After brief history of mechanosensation and the criteria of mechanical transduction channels are int...
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Chapter and Conference Paper
Differential Radiation Sensitivities of Arabidopsis Plants at Various Developmental Stages
Arabidopsis plants were exposed to γ-rays of 200 Gy at one vegetative and three reproductive stages such as 23, 30, 36, and 43 days after sowing the seeds (DAS). The plants irradiated at certain re...
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Chapter and Conference Paper
Using Efficient RBF Network to Identify Interface Residues Based on PSSM Profiles and Biochemical Properties
Protein-protein interactions play a very important role in many biological processes, for example, information transfer along signaling pathways, and enzyme catalysis. Recently, scientists tried to predict the...
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Chapter
Biophysical Methods
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Chapter
Significance of Protein Kinase A in Cancer
The system of cyclic nucleotides is one of the regulatory cascades whose initial step begins at the level of the external signal perception and whose final step is completed by phosphorylation of a number of s...
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Chapter
Selenium-induced apoptosis
Selenium is both an essential and a toxic trace element. It has been reported to induce cell growth and cell proliferation, but also cell death by necrosis or apoptosis. The biological action of selenium is de...
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Chapter
Plant Prevacuolar Compartments and Endocytosis
Prevacuolar compartments (PVCs) are membrane-bound organelles mediating protein traffic from both Golgi and plasma membrane to vacuoles in eukaryotic cells. Recent studies demonstrate that PVCs in plant ...
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Chapter and Conference Paper
Effect of Doxycycline-Regulated Calnexin and Calreticulin Expression on Specific Thrombopoietin Productivity of Recombinant CHO Cells
In an attempt to increase the specific TPO productivity (qTPO) of rCHO cells (CHO-TPO), the effect of expression level of calnexin (CNX) and calreticulin (CRT) on qTPO was investigated. To regulate the CNX and CR...
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Chapter and Conference Paper
Construction of Recombinant Escherichia coli Strains for Production of Poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)
Plastic wastes constitute a worldwide environmental problem, and the demand for biodegradable plastics has become high. One of the most impor tant characteristics of microbial polyesters is that they are therm...
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Chapter and Conference Paper
Production of Biodiesel Fuel by Transesterification of Rapeseed Oil
Fatty acid methyl esters (FAMEs) show large potential applications as diesel substitutes, also known as biodiesel fuel. Biodiesel fuel as renewable energy is an alternative that can reduce energy dependence on...