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    Novel Approaches to Identify Low-Penetrance Cancer Susceptibility Genes Using Mouse Models

    Studies of cancer predisposition have largely concentrated on the role of high-penetrance susceptibility genes. Less than 10% of the total human tumor burden, however, is accounted for by mutations in these ge...

    John P. de Koning, Jian-Hua Mao, Allan Balmain in Tumor Prevention and Genetics (2003)