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A Cost-Affordable Methodology of 3D Printing of Bone Fractures Using DICOM Files in Traumatology
Three-dimensional (3D) printing has gained popularity across various domains but remains less integrated into medical surgery due to its complexity....
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General skin and nasal decolonization with octenisan® set before and after elective orthopedic surgery in selected patients at elevated risk for revision surgery and surgical site infections—a single-center, unblinded, superiority, randomized controlled trial (BALGDEC trial)
BackgroundThe preoperative body surface and nasal decolonization may reduce the risk of surgical site infections (SSI) but yields conflicting results...
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Impact of Active learning model and prior knowledge on discovery time of elusive relevant papers: a simulation study
Software that employs screening prioritization through active learning (AL) has accelerated the screening process significantly by ranking an...
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Physical activity, gut microbiota and the nexuses of metabolic and psychological disorders in children and adolescents
The burden of health issues surrounding the children and adolescents (ChAds) population is of great concern. From metabolic disorders such as...
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Community health promotion and medical provision and impact on neonates (CHAMPION2) and support to rural India’s public education system and impact on numeracy and literacy scores (STRIPES2): an update to the study protocol (v 11) for a cluster randomised trial in Madhya Pradesh, India
BackgroundThis update outlines amendments to the CHAMPION2/STRIPES2 cluster randomised trial protocol primarily made due to the COVID-19 pandemic and...
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Antiplatelet therapy to prevent ischemic events in giant cell arteritis: protocol for a systematic review and meta-analysis
BackgroundGiant cell arteritis (GCA) is the most common systemic vasculitis in adults. Presenting features include new-onset headaches,...
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Automation of systematic reviews of biomedical literature: a sco** review of studies indexed in PubMed
BackgroundThe demand for high-quality systematic literature reviews (SRs) for evidence-based medical decision-making is growing. SRs are costly and...
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Ensemble Machine Learning and Predicted Properties Promote Antimicrobial Peptide Identification
AbstractThe emergence of antibiotic-resistant microbes raises a pressing demand for novel alternative treatments. One promising alternative is the...
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Functional Principal Component Analysis for Multiple Variables on Different Riemannian Manifolds
Functional principal component analysis (FPCA) is a very important dimension reduction tool for functional data analysis. The conventional FPCA...
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A Comparison of Estimation Methods for Shared Gamma Frailty Models
This paper compares six different estimation methods for shared frailty models via a series of simulation studies. A shared frailty model is a...
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Effect of in-line filtration in newborns: study protocol of the Intravenous Neonatal Central Access Safety (INCAS) randomized controlled trial
BackgroundParticulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk...
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The effectiveness and safety of acupoint herbal patching for allergic rhinitis: protocol for a systematic review and meta-analysis
BackgroundAllergic rhinitis (AR) is a common inflammatory disease of the nasal mucosa that is characterized by symptoms such as sneezing, nasal...
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Functional Causal Inference with Time-to-Event Data
Functional data analysis has proven to be a powerful tool for capturing and analyzing complex patterns and relationships in a variety of fields,...
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Study protocol for an adaptive, multi-arm, multi-stage (MAMS) randomised controlled trial of brief remotely delivered psychosocial interventions for people with serious mental health problems who have experienced a recent suicidal crisis: Remote Approaches to Psychosocial Intervention Delivery (RAPID)
BackgroundPeople with serious mental health problems (SMHP) are more likely to be admitted to psychiatric hospital following contact with crisis...
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Association of preserved ratio impaired spirometry with mortality and cardiovascular diseases: a systematic review and meta-analysis
BackgroundPreserved ratio impaired spirometry (PRISm) is a type of abnormal lung function. PRISm and mortality have been explored in several studies,...
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Role of central endpoint adjudication and challenges in trials on neonatal sepsis—a case of ProSPoNS trial
Despite progress in reducing the infant mortality in India, the neonatal mortality decline has been slower, necessitating concerted efforts to...
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An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial—an update to the published protocol
This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October...
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Binary classification with fuzzy logistic regression under class imbalance and complete separation in clinical studies
BackgroundIn binary classification for clinical studies, an imbalanced distribution of cases to classes and an extreme association level between the...
