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Contrast-enhanced mammography for surveillance in women with a personal history of breast cancer
PurposeWomen with a personal history of breast cancer have an increased risk of subsequent breast malignancy and may benefit from more sensitive...
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New horizons for the role of selenium on cognitive function: advances and challenges
Cognitive deficits associated with oxidative stress and the dysfunction of the central nervous system are present in some neurodegenerative diseases,...
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Trastuzumab-Deruxtecan: Redefining HER2 as a Tumor Agnostic Biomarker
Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2-positive malignancies across various tumor types. Through its...
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Differential Adherence to Free and Single-Pill Combination of Rosuvastatin/Ezetimibe: Findings from a Real-World Analysis in Italy
IntroductionAdherence to cardiovascular drug treatment can significantly benefit from a reduced pill burden, but data on this matter derived from...
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Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases
BackgroundLymphangioma is a rare cystic tumor that occurs across different locations. Retroperitoneal lymphangioma accounts for about 1% of all...
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Zinc Oxide Nanoparticles Attenuated Neurochemical and Histopathological Alterations Associated with Aluminium Chloride Intoxication in Rats
The present investigation explored the potential neuroprotective role of zinc oxide nanoparticles (ZnONPs) on aluminum chloride (AlCl 3 )-mediated...
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Comprehensive multiomics analysis of the signatures of gastric mucosal bacteria and plasma metabolites across different stomach microhabitats in the development of gastric cancer
PurposeAs an important component of the microenvironment, the gastric microbiota and its metabolites are associated with tumour occurrence,...
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Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma
BackgroundBRAF inhibitors are widely employed in the treatment of melanoma with the BRAF V600E mutation. However, the development of resistance...
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Comorbidities and survival of multiple myeloma patients diagnosed in Finland between 2000 and 2021
Advances in treatment have improved the survival of multiple myeloma (MM) patients, but the disease remains incurable. Here, in this nationwide...
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Effect of Hepatic Impairment on Trofinetide Exposures Using an In Silico Physiologically Based Pharmacokinetic Model
IntroductionTrofinetide is the first drug to be approved for the treatment of Rett syndrome. Hepatic impairment is not expected to affect the...
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3D airway geometry analysis of factors in airway navigation failure for lung nodules
BackgroundThis study aimed to quantitatively reveal contributing factors to airway navigation failure during radial probe endobronchial ultrasound...
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CAR-T cell therapy in AML: recent progress and future perspectives
Despite several small-molecule drugs that have revolutionized the current treatment strategy for acute myeloid leukemia (AML), hematopoietic stem...
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Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy
BackgroundEndocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα)....
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Advancements in the understanding and management of histiocytic neoplasms
Histiocytic neoplasms are rare diseases involving macrophages, dendritic cells, and monocytes. They include Langerhans cell histiocytosis (LCH),...
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Promoter profiles in plasma CfDNA exhibits a potential utility of predicting the efficacy of neoadjuvant chemotherapy in breast cancer patients
BackgroundGene expression profiles in breast tissue biopsies contain information related to chemotherapy efficacy. The promoter profiles in cell-free...
