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A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was standardized and used to...
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Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous...
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Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multilateral agencies. The...
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Association between brominated flame retardants (PBDEs and PBB153) exposure and hypertension in U.S. adults: results from NHANES 2005–2016
BackgroundBrominated Flame Retardants (BFRs) have attracted widespread concern due to their environmental persistence and potential toxicity. This...
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Effects of air pollution on global health: evidence from the global burden of disease study in the BRICS countries
PurposeConsidering the dynamic influence of environmental, social, economic, and political factors in the emergence and growth of the BRICS countries...
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A multi-biomarker micronucleus assay using imaging flow cytometry
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screening assays designed to...
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A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m 6 A) modifications. A better understanding of the...
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Mental Health Stigma in the Workplace and its Association with Possible Actions of Managers to Prevent Sickness Absence of Employees with Mental Health Problems in the Swedish Private Sector: a Video Vignette Study
PurposeMental health problems (MHPs) are subjected to workplace stigma and can deteriorate into common mental disorders (CMDs) and sickness absence...
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Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different...
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Influence of sustained mild dehydration on thermoregulatory and cognitive functions during prolonged moderate exercise
PurposeThe current study investigated whether sustained mild dehydration affects thermoregulatory function and cognitive performance during prolonged...
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Factors Related to the Recurrence of Sickness Absence Due to Common Mental Health Disorders: A Systematic Review
PurposeEmployees who experience sickness absence (SA) due to common mental disorders (CMD) are at increased risk of recurrent sickness absence (RSA)....
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A modified step–ramp–step protocol to prescribe constant-speed exercise in treadmill running
PurposeThis study investigated whether a running-adapted version of the cycling-based “step–ramp–step” (SRS) protocol would improve prediction of
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Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle
Resistance training activates mammalian target of rapamycin (mTOR) pathway of hypertrophy for strength gain, while endurance training increases...
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Polarized running training adapted to versus contrary to the menstrual cycle phases has similar effects on endurance performance and cardiovascular parameters
PurposeThis study compared the effects of polarized running training adapted to the menstrual cycle (MC) phases versus polarized training adapted...
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Neuauflage des TAEG Fragebogens: Technikaffinität valide und multidimensional mit einer Kurz- oder Langversion erfassen
A widely used instrument for standardized assessment of affinity for technology is the 19-item TAEG questionnaire (Karrer et al.
2009 ). It assesses... -
Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction
BackgroundThe effects of air pollution on endothelial function remain unclear across populations. We aimed to use brachial artery flow-mediated...
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Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More efficacious clinical...
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Independent and joint associations of multiple metals exposure with vital capacity index: a cross-sectional study in Chinese children and adolescents
ObjectiveThe current study aimed to explore the relationships between urinary metals and vital capacity index (VCI) in 380 children and adolescents...
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Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism
BackgroundAutism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal...
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Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare
PurposeTo develop and validate prediction models for the risk of future work absence and level of presenteeism, in adults seeking primary healthcare...