Search
Search Results
-
The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients
BackgroundStroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in...
-
Genetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery
BackgroundOne of the major hurdles in clinical genetics is interpreting the clinical consequences associated with germline missense variants in...
-
Clinical and genomic features of Mycobacterium avium complex: a multi-national European study
BackgroundThe Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently...
-
Exome sequencing in undiagnosed congenital myopathy reveals new genes and refines genes–phenotypes correlations
BackgroundCongenital myopathies are severe genetic diseases with a strong impact on patient autonomy and often on survival. A large number of...
-
Fermentation-mediated sustainable development and improvement of quality of plant-based foods: from waste to a new food
Food waste and by-products are generated throughout the food processing and storage chain. In a world facing climate collapse and limited space for...
-
Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species
BackgroundDespite technological advances in radiotherapy, cancer cells at the tumor margin and in diffusive infiltrates can receive subcytotoxic...
-
Comparative Functional Characterization of nst1, nst2, and nst3 in Arabidopsis thaliana Uncovers Previously Unknown Functions in Diverse Developmental Pathways Beyond Secondary Wall Formation
The regulation of secondary cell wall formation in Arabidopsis thaliana has been extensively studied with NST1 , NST2 , and NST3 playing key roles in...
-
Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease
Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating metabolic dysfunction-associated steatotic liver disease...
-
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
BackgroundRestraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and...
-
Optimization of protease production using Bacillus velezensis through response surface methodology and investigating its applications as stain remover
The aim of this research work was to evaluate the potential of Bacillus velezensis for proteases production by employing eggshells and egg membrane...
-
Bone metabolism – an underappreciated player
Bone is constantly being remodeled, and this process is orchestrated by a dynamic crosstalk of bone cells, including osteoclasts, osteoblasts, and...
-
PowerAI-Diabetes: Review of glycemic and lipid variability to predict cardiovascular events in Chinese diabetic population
The aim of this study is to review the predictive value of visit-to-visit variability in glycaemic or lipid tests for forecasting major adverse...
-
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer’s disease
Alzheimer’s disease (AD) is influenced by a variety of modifiable risk factors, including a person’s dietary habits. While the ketogenic diet (KD)...
-
Relationship between microbial protein and amino acid metabolism in fermented grains of long fermentation period strong-flavor Baijiu
The long fermentation period constitutes a crucial process for enhancing the quality of base liquor in the production of Chinese strong-flavor...
-
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy....
-
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases
Even with systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC), peritoneal metastases (PM)...
-
Enzymes in the production of cultivated meat products
Enzymes play a pivotal role in meat processing and maturation, starting with endogenous enzymes that catalyse a partial proteolysis in natural meat...
-
Algal biorefinery: focus on cosmeceuticals
Amidst the ever-evolving landscape of cosmetics, algae and their derived products have captured substantial worldwide interest, heralding a new era...
-
16S amplicon sequencing of the gastrointestinal microbiota of Cirrhinus reba and isolation of an autochthonous probiotic using culture based approaches
The microbiome in the gastrointestinal tract (GIT) of fish influences host health in both beneficial and detrimental ways and understanding the gut...
-
Unveiling the potential of systems biology in biotechnology and biomedical research
“In silico organisms” are computational genome-scale metabolic models used in systems and synthetic biology developed by constraint-based metabolic...
