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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal...
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A One Health framework for exploring zoonotic interactions demonstrated through a case study
The eco-epidemiology of zoonoses is often oversimplified to host-pathogen interactions while findings derived from global datasets are rarely...
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Impact of bedaquiline regimen on the treatment success rates of multidrug-resistant tuberculosis patients in Egypt
Bedaquiline (BDQ), an innovative anti-tuberculous (TB) agent, has attracted attention for its potential effectiveness against drug-resistant TB. This...
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Building a translational cancer dependency map for The Cancer Genome Atlas
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients....
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Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein,...
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Temporal dynamics of climate change exposure and opportunities for global marine biodiversity
Climate change is exposing marine species to unsuitable temperatures while also creating new thermally suitable habitats of varying persistence....
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p53 at the crossroads of tumor immunity
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent...
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Long-term biotic homogenization in the East African Rift System over the last 6 million years of hominin evolution
Eastern Africa preserves the most complete record of human evolution anywhere in the world but we have little knowledge of how long-term...
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Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality,...
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Laboratory infrared spectra and fragmentation chemistry of sulfur allotropes
Sulfur is one of six life-essential elements, but its path from interstellar clouds to planets and their atmospheres is not well known. Astronomical...
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Relation between attitudes towards pornography consumption, peer sexual behaviors and attitudes towards premarital sex among the college students in Guangdong province, China
Limited research exists on college students’ attitudes towards premarital sex in China, despite its increasing prevalence among youth. This study...
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First Record of Telenomus dilophonotae (Hymenoptera, Scelionidae), Parasitizing Eggs of Erinnyis ello (Lepidoptera, Sphingidae) in Western Paraná, Brazil, with Molecular Characterization and Records of Occurrences
There are few records for Telenomus dilophonotae Cameron, 1913 (Hymenoptera, Scelionidae) from South America. In Brazil, the first occurrence was...
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Prenatal genetic diagnosis of fetuses with dextrocardia using whole exome sequencing in a tertiary center
To evaluate the genetic etiology of fetal dextrocardia, associated ultrasound anomalies, and perinatal outcomes, we investigated the utility of whole...
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Simultaneous production of syngas and carbon nanotubes from CO2/CH4 mixture over high-performance NiMo/MgO catalyst
Direct conversion of biogas via the integrative process of dry reforming of methane (DRM) and catalytic methane decomposition (CDM) has received a...
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Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines
Bictegravir, a key second-generation integrase strand transfer inhibitor in the treatment of HIV, is subject to active efflux transport mediated by...
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An efficient learning based approach for automatic record deduplication with benchmark datasets
With technological innovations, enterprises in the real world are managing every iota of data as it can be mined to derive business intelligence...
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Impact of corrupt admission on the mental health of Chinese adolescents
Through preferential treatment by education officials or through bribery, some adolescents can obtain admission to a junior high school. However, it...
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Transcriptomic profiling and discovery of key transcription factors involved in adventitious roots formation from root cuttings of mulberry
ARs plays a crucial role in plant morphogenesis and development. The limited and inefficient rooting of scions poses a significant challenge to the...
