Search
Search Results
-
Human Infant Fecal Microbiota Differentially Influences the Mucosal Immune Pathways Upon Influenza Infection in a Humanized Gnotobiotic Pig Model
In this study, we evaluated the impact of human gut microbiota on the immune pathways in the respiratory tract using a gnotobiotic (Gn) piglet model....
-
Establishing Host–Virus Link Through Host Metabolism: Viral DNA SIP Validation Using T4 Bacteriophage and E. coli
DNA Stable Isotope Probing is emerging as a potent methodology for investigating host–virus interactions, based on the essential reliance of viruses...
-
Mechanistic Investigation on the Antibacterial Activity of Biogenic Silver Nanoparticles Prepared Using Root Extract of Sarsaparilla and Demonstrated their In Vivo Efficacy in Zebrafish Model
Antibiotic success rates are decreasing as drug-resistant bacteria become more prevalent, prompting the development of new therapeutic drugs. Herein,...
-
Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil
Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue...
-
Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat model
Oxidative stress is a key contributor to AD pathology. However, the earliest role of pre-plaque neuronal oxidative stress, remains elusive. Using...
-
Development of Rapid Disk Diffusion Device Using Laser Speckle Formation Technology for Rapid Antimicrobial Susceptibility Testing
The escalation of antimicrobial resistance (AMR) due to the excessive and inappropriate use of antimicrobials has prompted the urgent need for more...
-
Optimizing Real-Time PCR for Accurate Identification and Quantification of Common Probiotic Bacteria in Iranian Probiotic Dairy Products
The effectiveness of probiotics for health depends on the strain type and dosage. In this study, we endeavored to establish a robust quantitative...
-
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
BackgroundN 1 -Methyladenosine (m 1 A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the...
-
Butyricimonas faecihominis: an atypically resistant bacterium implicated in abscess formation - a case report
BackgroundThis case report presents a unique instance of abscesses with an uncommon pathogen isolated from blood cultures.
Case presentation ... -
A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels
Voltage-gated K + (K V ) channels govern K + ion flux across cell membranes in response to changes in membrane potential. They are formed by the assembly...
-
SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells
BackgroundNor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to...
-
Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
-
C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
-
Increasing the efficiency of CRISPR/Cas9-mediated genome editing in the citrus postharvest pathogen Penicillium digitatum
BackgroundPenicillium digitatum is a fungal plant pathogen that causes the green mold disease in harvested citrus fruits. Due to its economical...
-
Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical...
-
Lysinibacillus pinottii sp. nov., a novel species with anti-mosquito and anti-mollusk activity
An isolate of a Gram-positive, strictly aerobic, motile, rod-shaped, endospore forming bacterium was originally isolated from soil when screening and...
-
Effects of warm oceanographic anomalies on the foraging variability of northern elephant seals
Evaluation of stable carbon (δ 13 C) and nitrogen (δ 15 N) isotopes in marine organisms over time addresses how environmental variability (e.g., El...
-
Enhancing monolignol ferulate conjugate levels in poplar lignin via OsFMT1
BackgroundThe phenolic polymer lignin is one of the primary chemical constituents of the plant secondary cell wall. Due to the inherent plasticity of...
-
Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
BackgroundAge-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus...
-
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth
Our study employs pooled CRISPR screens, integrating 2D and 3D culture models, to identify miRNAs critical in Breast Cancer (BC) tumoursphere...