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Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study
BackgroundLung cancer still ranks first in the mortality rate of cancer. Uric acid is a product of purine metabolism in humans. Its presence in the...
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Association between Copper Exposure and Cognitive Function: A Cross-Sectional Study in a County, Guangxi, China
There has been growing attention to the impact of copper exposure on cognitive function; however, current research on the specific information...
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Risk factors for Non-Hodgkin’s lymphoma in autoimmune disease: a large database analysis
Immune dysregulation in autoimmune diseases (ADs) is a risk factor for the development of Non-Hodgkin’s lymphoma (NHL). However, the underlying...
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A randomized phase III double-blind placebo-controlled trial of first-line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu-positive metastatic breast cancer: a trial of the ECOG-ACRIN Cancer Research Group (E1105)
BackgroundIn 2008, bevacizumab received accelerated Food and Drug Administration (FDA) approval for use in human epidermal growth factor receptor 2...
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Participants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study
BackgroundThe period between cancer diagnosis and surgery presents an opportunity for trials to assess the feasibility of behaviour change...
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Establishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq
Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its...
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Clinical outcome predictors for metastatic renal cell carcinoma: a retrospective multicenter real-life case series
Over the last decades, the therapeutic armamentarium of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of...
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Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy arising from immature thymocytes. Unlike well-known oncogenic transcription...
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Review on radiomic analysis in 18F-fluorodeoxyglucose positron emission tomography for prediction of melanoma outcomes
Over the past decade, several strategies have revolutionized the clinical management of patients with cutaneous melanoma (CM), including...
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Trypanocidal resistance in two cattle farms using varying diagnostic techniques in southwest Nigeria
African animal trypanosomosis (AAT) affects the livestock industry, impacting protein intake and herders’ livelihoods. Despite the presence of vector...
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Infectious mononucleosis complicated by transitory Epstein-Barr virus infection of T and natural killer cells
Epstein-Barr virus (EBV) typically infects B cells in infectious mononucleosis (IM), but a rare case shows EBV infection in T cells. Seven cases of...
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Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years
Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large...
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The origin of ovarian Leydig cells: a possibly solved enigma?
Over the years, the origin of ovarian Leydig cells has been, and still is, a topic subject to deep debate. Seven years ago, we proposed that this...
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Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers
BackgroundThe long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal...
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The pathogenesis mechanism and potential clinical value of lncRNA in gliomas
Glioma is the most common malignant tumor in the central nervous system, and its unique pathogenesis often leads to poor treatment outcomes and...
