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Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
BackgroundExposure of humans and animals to heavy metals is increasing day-by-day; thus, lead even today remains of significant public health...
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Effect of Post-transplant Dietary Restriction on Hematopoietic Reconstitution and Maintenance of Reconstitution Capacity of Hematopoietic Stem Cells
Hematopoietic cell transplantation (HCT) is an important therapy for many hematological malignancies as well as some non-malignant diseases....
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Neural pathways that compel us to scratch an itch
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical stimuli with the potential...
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A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To enable robust inferences from...
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From Gut Microbiomes to Infectious Pathogens: Neurological Disease Game Changers
Gut microbiota and infectious diseases affect neurological disorders, brain development, and function. Compounds generated in the gastrointestinal...
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Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...
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Pancreatic Differentiation of Oral Minor Salivary Gland Stem Cells
IntroductionStem cells from various sources including major salivary glands have been used to establish pancreatic differentiation in an attempt to...
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Programmed RNA editing with an evolved bacterial adenosine deaminase
Programmed RNA editing presents an attractive therapeutic strategy for genetic disease. In this study, we developed bacterial deaminase-enabled...
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miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization
BackgroundColorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present...
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High-throughput combination assay for studying biofilm formation of uropathogenic Escherichia coli
Uropathogenic Escherichia coli , the most common cause for urinary tract infections, forms biofilm enhancing its antibiotic resistance. To assess the...
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The origin of ovarian Leydig cells: a possibly solved enigma?
Over the years, the origin of ovarian Leydig cells has been, and still is, a topic subject to deep debate. Seven years ago, we proposed that this...
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Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the...
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Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway
BackgroundChronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high death rates. Aucubin is an iridoid glycoside...
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A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is crucial for progress in vascular biology and regenerative...
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Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
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Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological tissues of the embryo and...
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Role of ferroptosis in radiation-induced soft tissue injury
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic...
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Functional multi-organelle units control inflammatory lipid metabolism of macrophages
Eukaryotic cells contain several membrane-separated organelles to compartmentalize distinct metabolic reactions. However, it has remained unclear how...
