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Bone metabolism – an underappreciated player
Bone is constantly being remodeled, and this process is orchestrated by a dynamic crosstalk of bone cells, including osteoclasts, osteoblasts, and...
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PowerAI-Diabetes: Review of glycemic and lipid variability to predict cardiovascular events in Chinese diabetic population
The aim of this study is to review the predictive value of visit-to-visit variability in glycaemic or lipid tests for forecasting major adverse...
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Diastereodivergent nucleophile–nucleophile alkene chlorofluorination
The selective hetero-dihalogenation of alkenes provides useful building blocks for a broad range of chemical applications. Unlike...
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An ‘activator-repressor’ loop controls the anthocyanin biosynthesis in red-skinned pear
The color of red-skinned pear ( Pyrus spp.) is primarily attributed to accumulation of anthocyanins, which provide nutritional benefits for human...
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Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
The purpose of this study is to explore the shared molecular pathogenesis of traumatic brain injury (TBI) and high-grade glioma and investigate the...
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Ribosomal proteins: the missing piece in the inflammation puzzle?
Ribosomal proteins (RPs) are constituents of macromolecular machinery, ribosome that translates genetic information into proteins. Besides ribosomal...
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A Theoretical Investigation for Exploring the Potential Performance of Non-Fullerene Organic Solar Cells Through Side-Chain Engineering Having Diphenylamino Groups to Enhance Photovoltaic Properties
The development of ecofriendly fabrication phenomenon is essential requirement for commercialization of non-fullerene acceptors. Recently, end-capped...
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A Review of Nanotechnology-Enabled Fluorescent Chemosensors for Environmental Toxic Ion Detection
This review examines the utilization of nanotechnology-based chemosensors for identifying environmental toxic ions. Over recent decades, the creation...
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In vitro anticancer study of novel curcumin derivatives via targeting PI3K/Akt/p53 signaling pathway
Four new series of curcumin derivatives bearing NO-donating moiety were synthesized via etherification, nucleophilic substitution, and Knoevenagel...
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing
The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short...
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded...
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Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer’s disease
Alzheimer’s disease (AD) is influenced by a variety of modifiable risk factors, including a person’s dietary habits. While the ketogenic diet (KD)...
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Clinical Characteristics, Therapeutic Options, and Outcomes in Hyperphosphatemic Tumoral Calcinosis: A Systematic Review
This systematic review was performed to understand better the myriad presentations, various therapeutic options, response to therapy, and its...
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A Pyrazine-Based Chromophore Photophysical Properties and its Detection for Hydrazine and Acid Vapors
Designed and synthesized linear pyrazine-based D-π-A-π-A probe is investigated to study the colorimetric and emission properties with different...
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Characterization of TEMPO-Oxidized Cellulose Nanofiber From Biowaste and Its Influence on Molecular Behavior of Fluorescent Rhodamine B Dye in Aqueous Suspensions
Cellulose nanofiber (CNFs) obtained through TEMPO oxidation was structurally characterized using FT-IR (Fourier Transformed Infrared) and SEM...
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Cryptic enzymatic assembly of peptides armed with β-lactone warheads
Nature has evolved biosynthetic pathways to molecules possessing reactive warheads that inspired the development of many therapeutic agents,...
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Transition transferases prime bacterial capsule polymerization
Capsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses. Capsule...
