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Hodgkin lymphoma and liquid biopsy: a story to be told
Hodgkin lymphoma (HL) represents a neoplasm primarily affecting adolescents and young adults, necessitating the development of precise diagnostic and...
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Dispersal of Pseudomonas aeruginosa biofilm using TDS97 bacteriophage and recombinant alginate lyase enzyme
Pseudomonas aeruginosa is an opportunistic human pathogen capable of forming biofilms and contaminate medical devices and food. Bacteremia caused by...
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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
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Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling
Hepatocellular carcinoma (HCC), a widely prevalent malignancy strongly linked to inflammation, remains a significant public health concern....
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Economic and Technical Assessment of the Chinese Plum Varieties Using Multi-Criteria Analysis Methods
Globally, plums are among the most grown and consumed fruit species. Considering China as the leader in plum production, there are intentions to...
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Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However,...
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite...
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Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion
BackgroundWe have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human...
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Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes
BackgroundInherited retinal dystrophies (IRD) are one of the main causes of incurable blindness worldwide. IRD are caused by mutations in genes that...
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Experimental design optimisation and validation by accuracy profile of a novel method for Hg speciation analysis by HPLC-ICP-MS and application to Total Diet Studies
This study addresses the development and validation of an analytical method for speciation analysis of mercury (inorganic/Hg 2+ and methylmercury/CH 3 Hg
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RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy
BackgroundAn increasing number of studies have demonstrated the association of circular RNAs (circRNAs) with the pathological processes of various...
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BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disease in adults. Currently, there are no known drugs or clinical approaches...
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Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development
Circadian disruption, as a result of shiftwork, jet lag, and other lifestyle factors, is a common public health problem associated with a wide range...
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Atypical Antiadrenergic Effect of Refralon as a Mechanism of High Antiarrhythmic Effectiveness
We studied the effect of Refralon on the electrophysiological properties of the supraventricular myocardium against the background of adrenergic...
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Manipulating disorder within cathodes of alkali-ion batteries
The fact that ordered materials are rarely perfectly crystalline is widely acknowledged among materials scientists, but its impact is often...
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RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway
Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow...
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NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell...
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The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway
Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2...
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
