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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
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Atypical Antiadrenergic Effect of Refralon as a Mechanism of High Antiarrhythmic Effectiveness
We studied the effect of Refralon on the electrophysiological properties of the supraventricular myocardium against the background of adrenergic...
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Description of a new species of Ixodes Latreille, 1795 (Acari: Ixodidae), parasite of rodents (Rodentia: Muridae) in Malaysia and Vietnam
Ixodes abramovi n. sp. (Acari: Ixodidae) is described based on females ex various rodents (Rodentia: Muridae) from Malaysia and Vietnam. Females of...
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RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway
Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow...
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Genome-wide association study for cashmere traits in Inner Mongolia cashmere goat population reveals new candidate genes and haplotypes
BackgroundThe cashmere goat industry is one of the main pillars of animal husbandry in Inner Mongolia Autonomous Region, and plays an irreplaceable...
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Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp
BackgroundNeither a TYRP1-mediated highly conserved genetic network underlying skin color towards optimum defense nor the pathological tendency of...
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Antimicrobial Peptides: Potential Alternative to Antibiotics and Overcoming Limitations for Future Therapeutic Applications
Among all health-related issues, the rising concerns about drug resistance led to the look for alternative pharmaceutical drugs that are effective...
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NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell...
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The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway
Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2...
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Experimental design optimisation and validation by accuracy profile of a novel method for Hg speciation analysis by HPLC-ICP-MS and application to Total Diet Studies
This study addresses the development and validation of an analytical method for speciation analysis of mercury (inorganic/Hg 2+ and methylmercury/CH 3 Hg
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RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy
BackgroundAn increasing number of studies have demonstrated the association of circular RNAs (circRNAs) with the pathological processes of various...
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Cytogenetic analysis of meiotic behaviour and stability in a trigeneric hybrid (triticale x trigopiro)
Trigeneric hybrids in Triticeae may help to establish evolutionary relationships among different genomes present in the same cellular genetic...
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Exploring putative drug properties associated with TNF-alpha inhibition and identification of potential targets in cardiovascular disease using machine learning-assisted QSAR modeling and virtual reverse pharmacology approach
Cardiovascular disease is a chronic inflammatory disease with high mortality rates. TNF-alpha is pro-inflammatory and associated with the disease,...
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Extracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma
BackgroundAnlotinib is a targeted therapy indicated for some malignancies, including advanced non-small cell lung cancer (NSCLC). However,...
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Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats
BackgroundBreeding polled goats is a welfare-friendly approach for horn removal in comparison to invasive methods. To gain a comprehensive...
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Dispersal of Pseudomonas aeruginosa biofilm using TDS97 bacteriophage and recombinant alginate lyase enzyme
Pseudomonas aeruginosa is an opportunistic human pathogen capable of forming biofilms and contaminate medical devices and food. Bacteremia caused by...
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Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However,...
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite...
