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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans
Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme...
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Physical activity is associated with lower mortality in adults with obesity: a systematic review with meta-analysis
BackgroundObesity is a complex chronic disease associated with several adverse health outcomes that increase mortality risk. Physical activity (PA)...
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Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and...
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Temporal relationship between hepatic steatosis and fasting blood glucose elevation: a longitudinal analysis from China and UK
BackgroundThe link between nonalcoholic fatty liver disease and type 2 diabetes has not been fully established. We investigated the temporal...
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Comparison of FGM prevalence among Nigerian women aged 15–49 years using two household surveys conducted before and after the COVID-19 pandemic
BackgroundDue to its economic burden and change of focus, there is no gainsaying of the potential impacts of the COVID-19 pandemic on the progress of...
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Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant...
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Etiology-specific incidence and mortality of diarrheal diseases in the African region: a systematic review and meta-analysis
BackgroundDiarrheal diseases substantially affect public health impact in low- and middle-income countries (LMIC), particularly in Africa, where...
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Survey on pattern of myopia in school children in Hangzhou after the COVID-19 pandemic: a school-based vision screening study
BackgroundMyopia is a major health issue around the world. Myopia in children has increased significantly during the COVID-19 pandemic in China, but...
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The association between air pollution and obesity: an umbrella review of meta-analyses and systematic reviews
The objective of this umbrella review was to investigate comprehensive and synthesized evidence of the association between ambient air pollution and...
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A two-pronged approach to understanding reciprocity and mental health relationship in develo** countries: evidence from young informal construction workers in Nigeria
BackgroundMental health problems disproportionately affect young people in develo** countries. However, there is limited research on help-seeking...
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The spectrum of health conditions in community-based cross-sectional surveys in Southeast Asia 2010-21: a sco** review
BackgroundSoutheast Asia is undergoing an epidemiological transition with non-communicable illnesses becoming increasingly important, yet infectious...
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Unravelling factors influencing demand for modern contraception and evaluating coverage progress since 2015 in Ethiopia, Kenya, and Nigeria: insights from multilevel and geostatistical modelling
IntroductionThe United Nations established the Sustainable Development Goals (SDGs) in 2015 to enhance global development. In this study, we examine...
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Sedentary behavior is associated with the mental health of university students during the Covid-19 pandemic, and not practicing physical activity accentuates its adverse effects: cross-sectional study
BackgroundMovement behaviours, such as sedentary behavior (SB) and physical inactivity, have become a public health issue due to their implications...
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Maternal distress, parenting stress, maladaptive parenting and children’s problematic media use in China: evidence from 2022 spring in Shanghai
The COVID-19 lockdown has forced young children to spend more time on media and significantly impacted their mothers’ mental health. This study...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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Spatial and trend analysis of gestational syphilis cases in Brazil from 2011 to 2020: an ecological study
ObjectivesTo analyze the rate of gestational syphilis (GS) based on temporal trends over 11 years, as well as the spatial distribution of GS in...
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The impact of sleep quality on emotion regulation difficulties in adolescents: a chained mediation model involving daytime dysfunction, social exclusion, and self-control
ObjectivePrevious studies have revealed associations between sleep quality and mental health, yet the comprehensive role of sleep quality, daytime...
