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The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway
Lifestyle influences physical and cognitive development during the period of adolescence greatly. The most important of these lifestyle factors are...
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Economic and Technical Assessment of the Chinese Plum Varieties Using Multi-Criteria Analysis Methods
Globally, plums are among the most grown and consumed fruit species. Considering China as the leader in plum production, there are intentions to...
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Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling
Hepatocellular carcinoma (HCC), a widely prevalent malignancy strongly linked to inflammation, remains a significant public health concern....
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Dispersal of Pseudomonas aeruginosa biofilm using TDS97 bacteriophage and recombinant alginate lyase enzyme
Pseudomonas aeruginosa is an opportunistic human pathogen capable of forming biofilms and contaminate medical devices and food. Bacteremia caused by...
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Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However,...
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite...
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Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion
BackgroundWe have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human...
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Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes
BackgroundInherited retinal dystrophies (IRD) are one of the main causes of incurable blindness worldwide. IRD are caused by mutations in genes that...
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Cytogenetic analysis of meiotic behaviour and stability in a trigeneric hybrid (triticale x trigopiro)
Trigeneric hybrids in Triticeae may help to establish evolutionary relationships among different genomes present in the same cellular genetic...
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RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway
Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow...
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Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approach
BackgroundStem cell-derived therapies hold the potential for treatment of regenerative clinical indications. Static culture has a limited ability to...
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Autophagy modulation effect on homotypic transfer of intracellular components via tunneling nanotubes in mesenchymal stem cells
BackgroundRecent studies have proved the role of autophagy in mesenchymal stem cell (MSCs) function and regenerative properties. How and by which...
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SPARC overexpression in allogeneic adipose-derived mesenchymal stem cells in dog dry eye model induced by benzalkonium chloride
BackgroundNowadays, companion and working dogs hold significant social and economic importance. Dry eye, also known as dry keratoconjunctivitis...
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Assessment of Production and Soil Conservation Potential of Aromatic Grasses Grown Under Shifting Cultivated Degraded Hill Slopes of Eastern Ghats, India
Unregulated shifting cultivation in Eastern Ghat, India has accelerated soil erosion rates and caused unproductive land area forcing the local tribes...
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The Effect of Exercise on Mesenchymal Stem Cells and their Application in Obesity Treatment
Mesenchymal stem cells (MSCs) have demonstrated considerable potential in tissue repair and the treatment of immune-related diseases, but there are...
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Sewage surveillance of SARS-CoV-2 in Tokyo (May 2020–June 2022): method using high-throughput, fully-automated platform
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is shed in saliva, sputum, and feces of the novel coronavirus disease 2019 (COVID-19)...
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Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway
Ankle osteoarthritis is a relatively understudied condition and the molecular mechanisms involved in its development are not well understood. This...
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Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage
Hippocampal plasticity is closely related to physiological brain functions such as learning and memory. However, the effect of toll-like receptor 4...
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LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis
BackgroundAnti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as...
